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Streptomycin is a medication that requires careful monitoring due to its potential risks. It may lead to serious nerve damage, which can cause permanent hearing loss and balance issues. Certain factors can increase this risk, such as having kidney disease, using high doses, prolonged use, being over 60 years old, or experiencing severe dehydration. Here are important precautions and instructions to consider:

• Hydration: Maintain adequate fluid intake to prevent dehydration unless advised otherwise by your doctor.

• Pre-existing Conditions: Inform your doctor if you have existing kidney or hearing problems before starting treatment with streptomycin.

• Monitoring for Side Effects: Be vigilant for symptoms like ringing or roaring in the ears, headaches, hearing loss, balance disturbances, unusual sleepiness, dizziness, vision changes, or numbness/tingling of the skin. Report these to your healthcare provider immediately.

• Regular Health Checks: Your doctor will monitor your progress, including testing your hearing, kidney function, and streptomycin blood levels to minimize side effects. Treatment may be discontinued if kidney or hearing issues develop.

• Drug Interactions: Avoid concurrent use of other medications that could harm the kidneys or nerves, such as cidofovir, cisplatin, cyclosporine, and other aminoglycoside antibiotics like gentamicin or tobramycin.

• Surgical Considerations: Inform your doctor or dentist about your streptomycin use before any surgery, as it may interact with anesthetic drugs and increase the risk of side effects.

In the event of an overdose or severe adverse reaction, seek medical attention immediately. Always follow your healthcare provider's guidance to ensure safe use of this medication.

Common side effects:

• Nausea
• Vomiting
• Stomach upset
• Loss of appetite
• Mild pain, irritation, or redness at the injection site

Less common but important to monitor:

• Persistent diarrhea
• Muscle weakness
• Abnormal bleeding or bruising
• Rapid heartbeat
• Signs of infections such as a persistent cough or high fever
• Indications of kidney issues, like changes in urination
• Unusual fatigue
• Oral thrush
• Vaginal yeast infection

Serious side effects:

• Serious allergic reactions (rash, severe itching or swelling, especially around the face, tongue, or throat, intense dizziness, or difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• amphotericin B
• high doses of aspirin
• NSAIDs such as ibuprofen
• NSAIDs such as naproxen