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The safety information for this medication is crucial and outlines potential risks associated with its use. It is important to read these warnings carefully and discuss any concerns with your healthcare provider.

• Severe Allergic Reaction (Mazzotti Reaction): This serious allergic response may occur in rare cases, particularly in the treatment of river blindness with ivermectin (Stromectol). It is a reaction of the immune system to the dying parasitic worms. Symptoms may include rash, fever, joint pain, stomach upset, and swollen lymph nodes. Immediate medical attention is necessary, as this reaction can be life-threatening if untreated.

• Brain and Nervous System Issues: Rarely, individuals using ivermectin (Stromectol) for river blindness, especially those with concurrent African eye worm infection, might encounter issues affecting the brain and nervous system. Symptoms could manifest as severe sleepiness, confusion, or even coma. It is critical to seek medical help immediately if these symptoms occur. Generally, these issues resolve after stopping the medication, but they can be life-threatening if not addressed promptly.

No specific contraindications have been noted for this medication.

When taking this medication, you may experience some common side effects, which are usually mild. These include headaches, dizziness, muscle pain, nausea, and diarrhea. In some cases, individuals may also experience itching, with a small percentage reporting dizziness and nausea. If these side effects persist or worsen, it's advised to consult your healthcare provider for guidance.

For those being treated for "river blindness" (onchocerciasis), additional reactions may occur due to the dying parasites, particularly within the first four days of treatment. Such reactions can include joint pain, tender or swollen lymph nodes, eye swelling, redness or pain, weakness, vision changes, itching, rash, and fever. While these symptoms can be concerning, they are part of the body's response to treatment. However, if these effects become severe, seeking medical advice is important.

There are also serious side effects associated with this medication, though they are rare. These include neck or back pain, swelling of the face, arms, hands, or feet, chest pain, a fast heartbeat, drowsiness, confusion, and seizures. Immediate medical attention is necessary if any of these symptoms occur. Additionally, signs of a severe allergic reaction, such as rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing, require urgent care.

If you notice any side effects not listed here, it is important to communicate with your healthcare provider for further advice. Always be cautious and aware of your body's reactions to new medications, and ensure you have the necessary support and information to manage any side effects effectively.