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Mebendazole is no longer available in some regions due to a combination of factors, including changes in market demand, manufacturing decisions, and regulatory considerations. In some cases, pharmaceutical companies may have discontinued production due to low profitability or the availability of alternative treatments. Additionally, regulatory agencies may have updated guidelines or requirements that affected its availability. However, it is still available in certain countries and regions.

Mebendazole works by inhibiting the formation of microtubules in parasitic worms, which disrupts their ability to absorb glucose. This leads to a depletion of the worm's energy stores, ultimately causing their death. It is primarily used to treat infections caused by certain types of parasitic worms, such as pinworms, roundworms, and hookworms.

Mebendazole typically requires a prescription from a healthcare provider in many countries. However, regulations can vary depending on the location, so it is advisable to check with local pharmacies or healthcare providers for specific requirements.

Albendazole is often preferred over mebendazole due to its broader spectrum of activity against a variety of parasitic infections. It is effective against both intestinal and tissue parasites, whereas mebendazole is primarily used for intestinal worms. Additionally, albendazole has better absorption and can be more effective in treating systemic infections.

The effectiveness of mebendazole can be determined by the resolution of symptoms associated with the parasitic infection it is treating. This may include a reduction in gastrointestinal symptoms such as abdominal pain, diarrhea, or bloating. Additionally, follow-up stool tests may be conducted to confirm the absence of parasites. It is important for the patient to complete the full course of treatment and consult with a healthcare provider for proper evaluation.