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When taking this medication, there is a rare risk of developing severe skin rashes, which in some cases may be fatal. These rashes are more commonly observed in children compared to adults. The likelihood of a rash increases if you begin treatment with a high dose, escalate the dose rapidly, or combine this medication with certain other anti-seizure drugs, such as valproic acid or divalproex. Though rashes can develop at any point during treatment, most serious cases have been reported within 2 to 8 weeks of starting the medication.

• Seek immediate medical attention if you experience any skin rash or signs of a severe allergic reaction. This includes symptoms like hives, fever, swollen lymph nodes, severe dizziness, painful sores in or around the mouth and eyes, swelling of the face, tongue, or throat, difficulty breathing, or liver issues (e.g., persistent stomach or abdominal pain, ongoing nausea or vomiting, dark urine, or yellowing of the eyes or skin).
• Your healthcare provider will advise you on whether to discontinue the medication. Note that even after stopping the medication, there remains a risk that a rash could become life-threatening or result in permanent scarring or other complications.

You might experience mild side effects such as dizziness, drowsiness, headache, vomiting, or an upset stomach. These symptoms are generally not a cause for concern, but if they persist or worsen, it's important to inform your healthcare provider. It is reassuring to know that the majority of people taking this medication do not encounter serious side effects.

However, there are rare but serious side effects associated with this medication. A small number of individuals taking anticonvulsants may face mental health challenges, including depression or suicidal thoughts. If you or those around you notice any sudden changes in mood, thoughts, or behavior, it is crucial to seek medical advice immediately.

Additionally, seek urgent medical attention if you experience very serious side effects such as fainting, irregular heartbeat, unusual bruising or bleeding, a stiff neck, vision issues, loss of coordination, muscle pain, tenderness or weakness, or signs of kidney problems like changes in urine output. While these severe reactions are uncommon, being aware of them helps ensure prompt management.

This summary does not cover all possible side effects. If you experience any other unexpected symptoms, it is important to contact your healthcare provider for guidance.

Certain products can interact with this medication, including dofetilide and orlistat. Additionally, some medicines can influence how your body processes lamotrigine, potentially altering its effectiveness. These include hormonal birth control methods like pills and patches, estrogens, other seizure treatments such as phenobarbital, primidone, and valproic acid, as well as rifampin and ritonavir. If you're taking these drugs, your doctor might need to adjust your lamotrigine dosage.

Furthermore, this medication can reduce the effectiveness of hormonal contraceptives, which might lead to pregnancy. It's important to discuss with your doctor or pharmacist about using a reliable backup contraception method. Notify your doctor if you experience any new spotting or breakthrough bleeding, as these could indicate that your birth control is not working properly.

Inform your doctor or pharmacist if you're using other products that cause drowsiness, such as alcohol, marijuana (cannabis), antihistamines like cetirizine or diphenhydramine, medications for sleep or anxiety such as alprazolam, diazepam, or zolpidem, muscle relaxants, and opioid pain relievers like codeine.

Be sure to check the labels on all your medications, including those for allergies or cough and cold, as they might contain ingredients that cause drowsiness. Consult your pharmacist about the safe use of these products.

This medication may also interfere with certain laboratory tests, such as urine drug screenings, which could lead to inaccurate results. Ensure that all lab personnel and healthcare providers are aware that you are taking this medication.