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The use of Synjardy comes with important safety considerations due to potential risks associated with its ingredients, metformin and empagliflozin. Below is a summary of critical warnings and precautions:

• Lactic Acidosis: A rare but potentially fatal condition, lactic acidosis, may occur due to metformin buildup. This risk increases in individuals with kidney or liver disease, heart failure, the elderly, those undergoing surgery, imaging procedures with contrast dye, and those consuming large amounts of alcohol. Symptoms to watch for include unusual fatigue, dizziness, severe drowsiness, chills, blue or cold skin, muscle pain, breathing difficulties, irregular heartbeat, or abdominal pain with nausea/vomiting/diarrhea. Seek medical attention immediately if these occur.

• Diabetic Ketoacidosis (DKA): Empagliflozin can lead to DKA, a serious condition caused by insufficient insulin, leading to excessive ketones in the blood. Risk factors include prolonged fasting, surgery, fever, pancreatic issues, sudden insulin dose changes, and excessive alcohol intake.

• Dehydration and Kidney Issues: Empagliflozin may increase urination, leading to dehydration, low blood pressure, or acute kidney injury, especially in individuals older than 65, those with kidney issues, or those on diuretics or low-sodium diets.

• Genital and Urinary Tract Infections: The risk of serious genital and urinary infections, including yeast infections, increases. Those with a history of such infections are more vulnerable.

• Low Vitamin B12 Levels: Long-term use of Synjardy can reduce vitamin B12 levels, risking anemia. Regular monitoring and potential supplementation may be necessary.

• Amputation Risk: Although rare, there is a heightened risk of leg and foot amputations in individuals with peripheral artery disease, diabetic foot ulcers, or previous amputations.

• Allergic Reactions: Serious allergic reactions to Synjardy can occur. Symptoms such as rash, swelling, or breathing difficulties require immediate medical care.

• Hypoglycemia: Using Synjardy alongside insulin or insulin-raising drugs can lead to dangerously low blood sugar levels, especially in children aged 10 and older. Be aware of hypoglycemia symptoms like shakiness and confusion, and keep glucose tablets handy.

Contraindications include severe kidney problems, a history of severe acidosis, and previous allergic reactions to Synjardy's components. Consult your healthcare provider if any of these conditions apply to you. Always inform your healthcare provider of your complete medical history before starting Synjardy.

When taking this medication, you may experience some common side effects that are usually mild, such as nausea, vomiting, diarrhea, bloating, gas, headache, and a general feeling of weakness. It's important to monitor these symptoms and consult your healthcare provider if they persist or worsen. Additionally, there is a possibility of developing low blood sugar, which may manifest as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To address low blood sugar, it's advisable to keep glucose tablets or a quick source of sugar handy.

Some individuals may experience urinary tract infections, upper respiratory tract infections, or common cold symptoms like a cough or runny nose. Females might encounter vaginal yeast infections, while males could experience genital fungal infections. Other side effects include joint pain, frequent urination, indigestion, and a lack of energy. Although these side effects are not severe, they should be discussed with a healthcare provider if they occur.

There are rare but serious side effects that require immediate medical attention. These include lactic acidosis, characterized by confusion, weakness, rapid breathing, and nausea; ketoacidosis, which presents with symptoms like shortness of breath and fruity-smelling breath; and sudden kidney problems indicated by reduced urination and chest pain. Low blood pressure can lead to dizziness and confusion, while a serious genital infection may cause pain, swelling, or redness in the area. Severe allergic reactions, such as rash, blisters, and difficulty breathing, also necessitate urgent care.

This medication can increase the risk of lower limb amputation, especially in individuals with poor blood flow, nerve problems, or foot ulcers. Regular foot checks are recommended to catch any new pain or sores early. Dehydration is another potential risk, so it's vital to drink plenty of fluids and be alert to signs like dry mouth, thirst, fast heartbeat, or dizziness. If any severe symptoms arise, seek medical help immediately.