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This safety information outlines crucial warnings and guidelines for the use of glyburide. Carefully review these details and consult your healthcare professional if you have any concerns.

• Low Blood Sugar (Hypoglycemia): Glyburide can significantly reduce blood sugar levels, potentially leading to life-threatening situations. Symptoms of hypoglycemia include a rapid heartbeat, sweating, pale complexion, shakiness, confusion, and irritability. Always carry a quick source of sugar, such as four glucose tablets, 3-4 hard candies, half a cup of fruit juice, or half a can of regular soda, to address low blood sugar when necessary. Consult your healthcare provider or pharmacist if you have questions. Risk factors include changes in diet and exercise, alcohol consumption, use of other blood sugar-lowering medications, age 65 and older, and liver or kidney issues.

• Heart Problems: There is a potential risk that glyburide could increase the likelihood of fatal heart complications, similar to the medication tolbutamide, which belongs to the same sulfonylurea class. Discuss with your healthcare provider to weigh the benefits and risks of glyburide to determine if it suits your needs.

• Breakdown of Red Blood Cells: Your healthcare provider may test for glucose-6-phosphate dehydrogenase (G6PD) deficiency before starting glyburide. Individuals with this genetic condition who take sulfonylureas like glyburide have a heightened risk of hemolytic anemia, a condition where red blood cells are destroyed faster than they are produced. Regular blood monitoring may be required. Cease taking the medication and contact your provider immediately if you notice dark urine, fatigue, weakness, dizziness, or pale skin, as these could signal hemolytic anemia.

Contraindications: Do not use this medication if you have any of the following conditions, as it may pose significant health risks. Consult your healthcare provider before proceeding.

• Diabetic ketoacidosis
• Type 1 diabetes mellitus
• Concurrent use with bosentan (Tracleer)

When taking this medication, you may experience some mild side effects such as nausea, heartburn, bloating, and weight gain. These effects are usually temporary and not a cause for concern, but if they persist or worsen, it is advisable to inform a healthcare provider. Additionally, some individuals may encounter temporary allergic skin reactions like rashes or redness.

More serious side effects, though rare, require prompt medical attention. These include signs of infection such as a persistent sore throat and fever, easy bruising or bleeding, stomach pain, yellowing of the eyes or skin, dark urine, unusual tiredness or weakness, unexpected weight gain, mood changes, swelling of the hands or feet, and seizures. Severe allergic reactions, though uncommon, can manifest as rash, itching, swelling, severe dizziness, and difficulty breathing.

This medication can also lead to low blood sugar (hypoglycemia), particularly if you do not consume enough food or engage in intense physical activity. Symptoms include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, and tingling in the hands or feet. To manage this, it is helpful to carry glucose tablets or consume quick sources of sugar like candy or fruit juice. Conversely, high blood sugar (hyperglycemia) may present with increased thirst and urination, necessitating a review of your medication, exercise, or diet plan. Always maintain a regular meal schedule to prevent blood sugar fluctuations and consult your healthcare provider for any concerns.

Glyburide can interact with several medications, so it is important to inform your doctor and pharmacist about all drugs and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products.

One medication, bosentan, should generally not be used with glyburide. Your doctor might opt for a different therapy instead.

Some drugs, like acarbose, aspirin, and certain antibiotics or diabetes medications, are usually not recommended to be taken with glyburide. However, if necessary, your doctor may adjust the dosage or frequency of either medication to safely manage your treatment.

Additionally, there are medications that might increase the risk of certain side effects when used with glyburide. Despite this, the combination may be the most effective treatment for your condition. These include various beta-blockers (such as metoprolol, propranolol, and timolol), and other medications like clarithromycin and cyclosporine. Your doctor will carefully monitor your therapy and may adjust dosages as needed.

Moreover, some medications can affect your blood sugar levels, making them harder to control. It's crucial to regularly monitor your blood sugar and report any unusual symptoms to your doctor. They might need to adjust your diabetes medication, exercise, or diet accordingly.