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The following safety information outlines the potential risks and precautions associated with the use of colesevelam (Welchol). It is essential to review these warnings carefully and discuss any concerns with your healthcare provider.

• Increased Triglycerides and Pancreatitis: Colesevelam (Welchol) may raise blood triglyceride levels, leading to pancreatitis, which can cause symptoms such as nausea, vomiting, and abdominal pain radiating to the back. If these symptoms occur, discontinue use and seek immediate medical attention. Individuals with high triglyceride levels (300 mg/dL to 500 mg/dL), a history of pancreatitis, or diabetes are at higher risk.

• Digestive Tract Blockage: Some individuals taking colesevelam (Welchol) may experience blockages in the stomach or intestines. Before starting this medication, consult your healthcare provider if you have constipation or other digestive issues. If you have difficulty swallowing, consider the powder form to reduce choking risk. Report severe abdominal pain, new or worsening constipation, blood in the stool, or vomit resembling coffee grounds to your provider promptly. This risk is heightened in those with swallowing difficulties or changes in digestive tract anatomy.

• Vitamin Absorption Concerns: Colesevelam (Welchol) can interfere with the absorption of vitamins A, D, E, and K. Your provider may suggest taking vitamin supplements, but ensure these are taken at least 4 hours before colesevelam (Welchol) to prevent interaction.

• Medication Interactions: Colesevelam (Welchol) can affect the absorption of other oral medications, including birth control and thyroid medications. To avoid interactions, take these medications at least 4 hours prior to colesevelam (Welchol).

• Phenylketonuria (PKU) Considerations: If you have PKU, be cautious with the powder form of colesevelam (Welchol), as it may contain phenylalanine from aspartame. Verify with your pharmacist if the formulation is safe for your condition. Alternative formulations may be available.

Contraindications: Avoid using colesevelam (Welchol) if you have any of the following conditions, as they may pose serious health risks:

• Blood triglyceride levels exceeding 500 mg/dL.
• History of pancreatitis due to elevated triglycerides.
• History of stomach or intestinal blockage.

If any of these contraindications apply, consult your healthcare provider before using this medication.

When taking this medication, some individuals may experience common side effects such as constipation, which affects about 11% of users, and indigestion, noted in 8% of cases. These are generally mild, and simple lifestyle changes like increasing dietary fiber, staying hydrated, and regular exercise can help manage constipation. However, if these symptoms persist or worsen, consulting a healthcare provider is advisable.

Other less common symptoms include a sore throat, flu-like symptoms, runny nose, muscle aches, and occasional accidental injuries. Although these effects are typically not severe, it is important to monitor them and seek medical guidance if they become bothersome.

More serious side effects, although rare, demand immediate medical attention. These include pancreatitis, characterized by nausea, vomiting, and severe back-spreading stomach pain, as well as severe constipation, stomach pain, or any presence of blood in your stool, which might indicate stomach or intestine issues. Additionally, an allergic reaction could occur, presenting as a rash, itching, or swelling of the face, tongue, or throat, alongside severe dizziness or trouble breathing. Such symptoms require urgent care.

In some cases, the medication might affect blood sugar levels, leading to either hypoglycemia or hyperglycemia. Symptoms of low blood sugar include sudden sweating, shaking, a fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet, while high blood sugar symptoms involve increased thirst, urination, confusion, drowsiness, and rapid breathing. Managing blood sugar involves maintaining a regular meal schedule and being prepared with glucose tablets or a quick sugar source. Always inform your healthcare provider about any adverse reactions for appropriate adjustments in your treatment plan.