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Diarrhea, headache, nausea, vomiting, and changes in your sense of taste may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This medication may cause urine, sweat, saliva, or tears to turn brown-orange. This effect is harmless and will disappear when the medication is stopped. However, dentures and contact lenses may be permanently stained. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: muscle weakness/pain, signs of liver disease (such as nausea/vomiting that doesn't stop, yellowing eyes/skin, dark urine), easy bruising/bleeding, eye pain/redness, vision problems, signs of lupus (such as rash on nose and cheeks, new or worsening joint pain), signs of kidney problems (such as change in the amount of urine, pink/bloody urine). This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Amoxicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Some products that may interact with this drug are: azole antifungals (itraconazole, ketoconazole, posaconazole, voriconazole), clopidogrel, methotrexate (especially high-dose treatment), voriconazole. Rifabutin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include artemether/lumefantrine, lurasidone, mavacamten, phenytoin, ranolazine, suvorexant, calcium channel blockers (such as diltiazem, nifedipine, verapamil), certain products used to treat chronic hepatitis C (such as daclatasvir, ombitasvir/paritaprevir/ritonavir), among others. Other medications can affect the removal of omeprazole from your body, which may affect how omeprazole works. Examples include rifampin, St. John's wort, among others. Some products need stomach acid so that the body can absorb them properly. Omeprazole decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, among others. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Omeprazole is very similar to esomeprazole. Do not use any medications containing esomeprazole while using omeprazole. This medication may interfere with certain lab tests (including urine glucose test), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.