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You might experience mild side effects like nausea, vomiting, diarrhea, dizziness, or a sensation of spinning. These are generally not serious, but if they persist or worsen, it's important to seek advice from a healthcare professional. While many individuals taking this medication do not encounter severe side effects, there are some serious ones to be aware of. Contact your healthcare provider immediately if you experience difficulty swallowing, changes in hearing, joint pain or swelling, or signs of kidney or liver issues, such as altered urine output or color, loss of appetite, abdominal pain, or yellowing of the skin or eyes.

Minocycline can rarely increase pressure in the brain, a condition known as intracranial hypertension, especially in women of childbearing age who are overweight or have had this condition before. Symptoms include persistent headache, vision changes, or severe nausea and require urgent medical attention due to the risk of permanent vision loss. Additionally, a rare but severe intestinal condition caused by the bacteria C. difficile may occur, characterized by unrelenting diarrhea, abdominal pain, or blood in stools. Avoid anti-diarrhea or opioid medications if these symptoms appear, as they could exacerbate the condition.

Prolonged use of this medication might lead to oral thrush or a yeast infection. Be attentive to signs like white patches in the mouth or changes in vaginal discharge and consult your healthcare provider if they occur. Although a very serious allergic reaction is infrequent, immediate medical intervention is necessary if you experience symptoms such as persistent fever, swollen lymph nodes, rash, itching, severe dizziness, or breathing difficulties. Always report any unlisted side effects to your healthcare provider.