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When using desoximetasone (Topicort), it is essential to be aware of the associated safety information and warnings. This will help ensure safe usage and avoid potential complications. Please review the following points carefully and consult your healthcare provider if you have any questions or concerns:

• Altered Stress Hormone Levels: There is a possibility that your body may absorb excessive amounts of desoximetasone through the skin, particularly when applied over large areas, used for extended periods, or when the treated area is covered with tight bandages. Overexposure can lead to reduced production of stress hormones, such as cortisol, affecting bodily functions and causing symptoms like fatigue, nausea, and muscle pain. Usually, these issues resolve upon discontinuing the medication, though severe cases may require additional treatment. Be cautious if you are applying the medication on large body areas, using multiple topical steroids, covering the treated area, applying it on damaged skin, or if you have liver issues. Young children may also be at increased risk.

• Vision Problems: Although rare, using desoximetasone can increase the risk of developing cataracts and glaucoma. Inform your healthcare provider if you have any pre-existing eye conditions or a history of these issues before starting the medication. If you experience any vision changes while using this medication, promptly consult with your healthcare team or an eye specialist.

• Flammability (Topical Spray Only): The topical spray form of desoximetasone is flammable. To prevent fire hazards, keep the spray away from heat sources and open flames.

By adhering to these guidelines and precautions, you can help ensure the safe and effective use of desoximetasone (Topicort). Always follow your healthcare provider’s instructions and report any adverse effects you experience.

When using this medication, some individuals may experience mild side effects such as burning, itching, irritation, or dryness of the skin. These symptoms are generally temporary and should diminish as your body adjusts to the treatment. If they persist or worsen, it is advisable to consult a healthcare professional for guidance.

In certain cases, more serious side effects may occur. These include skin conditions like stretch marks, thinning or discoloration, acne, excessive hair growth, and folliculitis (small red bumps). Additionally, skin infections might worsen with use, particularly if redness, swelling, or irritation does not improve. It's important to be vigilant about these changes and seek medical advice if they occur.

Rarely, the medication may be absorbed into the bloodstream, potentially leading to systemic side effects associated with corticosteroid use. These effects include unusual or extreme tiredness, weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems. Children and those using the medication extensively or over large skin areas are more susceptible to these issues.

Though a very serious allergic reaction is rare, immediate medical attention is necessary if you experience a rash, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Always report any other unexpected side effects to your healthcare provider for further assessment.