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The safety and warning information below outlines critical risks and precautions associated with the use of this medication. Please read carefully and consult your healthcare provider with any concerns.

• Hormonal Changes: Excessive absorption of topical steroids like clobetasol through the skin can disrupt your body's hormone production, potentially affecting various body functions. This may include increased blood sugar levels or a tendency for your skin to bruise easily. The risk is higher with prolonged use or application over large skin areas. Your healthcare provider will aim to prescribe the minimal effective dose for the shortest duration. If extended use or application over large areas is necessary, you may need lab tests to ensure your body's stress hormone production remains adequate. Avoid using clobetasol for more than 2 weeks (or 4 weeks for the shampoo) unless advised by your provider. Risks increase with high potency steroid use, prolonged application, excessive dosage (over 2 grams daily), bandage coverage, and younger age.

• Elevated Blood Sugar: Long-term or extensive use of clobetasol may increase blood sugar levels, potentially leading to diabetes. Individuals with diabetes should monitor their blood sugar levels regularly while on this medication to ensure safety.

• Increased Infection Risk: Clobetasol can reduce your body's infection-fighting ability, increasing the risk of skin infections. It is crucial to use appropriate antifungal or antibacterial treatments if you have a skin infection while using clobetasol. Discontinue use and contact your healthcare provider immediately if you notice redness, pain, swelling, or pus at the application site.

• Skin Reactions: Extended use of clobetasol beyond the prescribed duration can lead to various skin issues, such as thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. Some of these changes may be irreversible. Your provider will prescribe the lowest effective dose for the shortest period necessary to mitigate severe skin reactions. Notify your healthcare provider immediately if you experience new or worsening skin problems. Risks are heightened with higher doses, extended use, and bandage coverage of the treated area.

When using this medication, you might initially experience some mild side effects such as burning, stinging, itching, irritation, dryness, or redness on the skin. These symptoms typically subside after a few days as your body adjusts. If they persist or worsen, it's important to inform your healthcare provider. In some cases, additional side effects like dry skin, rash, thinning of the skin, acne-like bumps, changes in skin color, stretch marks, heat rash, or hair loss (especially if used on the scalp) may occur. Although these are not common, they should be reported if they become bothersome or severe.

On rare occasions, the medication can be absorbed into the bloodstream, potentially leading to symptoms associated with excessive corticosteroid levels. Such symptoms include unusual tiredness, weight loss, headaches, swelling of ankles or feet, increased thirst or urination, and vision problems. These effects are more likely to occur in children or those using the medication extensively or over large skin areas. Immediate medical attention should be sought if these symptoms appear.

A serious allergic reaction to this medication is very rare, but you should watch for signs such as rash, severe dizziness, swelling (especially of the face, tongue, or throat), and trouble breathing. If any of these occur, seek medical help immediately. Although these lists cover many potential side effects, others might occur. Always contact your healthcare provider if you notice any new or concerning symptoms.