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This medication, Cholestyramine (Prevalite), has several important safety warnings and precautions that you should be aware of. It is crucial to understand these risks and consult your healthcare provider if you have any questions or concerns.

• Risk of Bowel Obstruction: This medication may cause constipation, which can lead to severe complications like bowel obstruction, especially if you have pre-existing digestive issues such as bile duct, stomach, or intestinal blockages. Notify your healthcare provider if you experience severe abdominal pain or constipation.

• Increased Bleeding Risk: Prolonged use of Cholestyramine (Prevalite) may increase the risk of bleeding. Contact your healthcare provider immediately if you notice symptoms such as blood in vomit, urine, black or tarry stools, gum bleeding, or unexplained bruising.

• Constipation Concerns: This medication may cause or worsen constipation. To alleviate this, increase your fluid intake, exercise regularly, and consider adding more fiber to your diet. Consult your healthcare provider about using a stool softener or laxative if needed.

• Dental Health Issues: Holding the medication in your mouth or sipping it for extended periods can discolor teeth, erode enamel, or lead to tooth decay. Maintain good oral hygiene by brushing regularly and visiting your dentist frequently.

• Drug Interactions: Cholestyramine (Prevalite) can interfere with the absorption of other medications. To minimize this, take other medications at least 1 hour prior or 4 to 6 hours after Cholestyramine. Consult your doctor or pharmacist for specific guidance.

• Low Folic Acid Levels: Long-term use may result in reduced folic acid levels, which is essential for blood cell formation. Symptoms include fatigue, weakness, pale skin, loss of appetite, rapid heartbeat, and shortness of breath. Discuss folic acid supplementation with your healthcare provider.

• Vitamin Absorption Interference: This medication may reduce the absorption of fat-soluble vitamins like A, D, E, and K. Consider taking vitamin supplements as advised by your healthcare provider, ensuring they are taken 1 hour before or at least 4 hours after Cholestyramine.

• Phenylketonuria (PKU) Warning: Cholestyramine contains phenylalanine, which can be harmful if you have PKU. It is important to consult your healthcare provider for alternative treatment options if you have this condition.

For any concerns or clarification, always consult your healthcare provider to ensure safe use of this medication.

Common side effects:

• constipation
• stomach discomfort
• nausea
• vomiting
• diarrhea
• bloating

Less common but important to monitor:

• severe stomach pain
• unusual bleeding or bruising
• severe constipation
• bloody, black, or tarry stools

Serious side effects:

• allergic reaction (rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Bezafibrate
• Deferasirox
• Dexamethasone
• Digoxin
• Mycophenolate mofetil
• Mycophenolic Acid

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aceclofenac
• Anisindione
• Cephalexin
• Cerivastatin
• Diclofenac
• Dicumarol
• Digitoxin
• Ezetimibe
• Furosemide
• Hydrochlorothiazide
• Levothyroxine
• Meloxicam
• Metronidazole
• Phenprocoumon
• Propranolol
• Valproic Acid
• Warfarin