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The following safety information is crucial for anyone using metronidazole (Flagyl). Please review these warnings and consult with your healthcare provider if you have any questions or concerns.

• Cancer Risk: Long-term use of metronidazole (Flagyl) may increase the risk of certain cancers, as studies in rats have shown a higher incidence of tumors. Avoid exceeding the dosage and duration prescribed by your healthcare provider.

• Severe Allergic Reactions: This medication can cause serious skin reactions, including Stevens-Johnson syndrome. Seek immediate medical attention if you experience symptoms such as rash, blisters, skin peeling, mouth sores, or high fever, as these may require discontinuation of the drug.

• Neurological Issues: Rarely, serious neurological problems like seizures or encephalopathy can occur. Look out for symptoms such as convulsions, coordination problems, or headaches, and seek medical care promptly. Your healthcare provider may advise stopping the medication if these symptoms arise.

• Liver and Kidney Concerns: If you have liver or kidney issues, metronidazole (Flagyl) could accumulate in your system, increasing the risk of side effects like nausea and seizures. Report symptoms such as jaundice, dark urine, or changes in urination to your provider, who may adjust your dosage accordingly.

• Fungal Infections: There is a heightened risk of fungal infections, including yeast infections, while taking this medication. Inform your healthcare team if you experience symptoms like itching, thick white discharge, or fever, as antifungal treatment may be necessary.

• Drug Resistance: Misuse of metronidazole (Flagyl), such as taking it more frequently or for longer than prescribed, can lead to drug-resistant infections. Follow your healthcare provider’s instructions precisely to ensure effectiveness against future infections.

• Reduced White Blood Cell Counts: Although rare, metronidazole (Flagyl) may lower white blood cell counts, increasing infection risk. Regular lab tests may be required to monitor this. Report symptoms like fever, mouth sores, or weakness to your provider.

• Drug Interactions: Metronidazole (Flagyl) can affect how your body processes other medications. Avoid combining it with drugs like disulfiram, as this can result in adverse effects such as delusions or hallucinations.

Contraindications: Do not use metronidazole (Flagyl) under the following conditions without consulting your healthcare provider, as it could pose significant health risks:

• Trichomoniasis during the first trimester of pregnancy.
• Recent use of disulfiram within the past two weeks.
• Consumption of alcohol.
• Cockayne syndrome, due to potential liver complications.

When taking this medication, some common side effects may occur, such as dizziness, headaches, and stomach upset, which are often mild and temporary. Nausea, vomiting, a metallic taste in the mouth, and changes in appetite or bowel habits like diarrhea or constipation are also reported. These effects usually do not cause serious harm and generally subside as the body adjusts to the medication. In some cases, the medication may cause harmless darkening of the urine, which will resolve once the treatment is completed.

There are more serious side effects that are rare but require immediate medical attention. These include severe dizziness, unsteadiness, seizures, and significant mood changes like confusion or trouble speaking. Other critical symptoms to watch for include eye pain, sudden vision changes, prolonged headaches, stiff neck, or tingling in the limbs. If you experience any of these, it is crucial to seek medical assistance promptly.

Additionally, there is a risk of developing oral thrush or a yeast infection with prolonged use, indicated by white patches in the mouth or changes in vaginal discharge. Allergic reactions, although uncommon, can be severe and require urgent care, especially if symptoms like rash, itching, swelling, or difficulty breathing occur. Kidney and liver problems are rare but serious, marked by symptoms such as swelling, yellowing of the skin or eyes, dark urine, or light-colored stools.

If you experience any side effects, whether common, severe, or unusual, it is important to monitor your symptoms and consult your healthcare provider for advice on managing them.

Metronidazole can interact with a variety of substances and medications, so it's essential to inform your doctor and pharmacist about all the medications and supplements you're taking, including prescription, over-the-counter, vitamins, and herbal products.

It is strongly advised not to use metronidazole alongside alcohol-containing products (like some cough syrups and aftershaves), propylene glycol-containing products, or the lopinavir/ritonavir solution. Additionally, avoid metronidazole if you are currently taking disulfiram or have taken it in the past two weeks, as this combination is not recommended.

This medication can also affect the results of certain lab tests, so ensure that all medical personnel are aware that you are using metronidazole.

Metronidazole should not be combined with certain medicines, such as Amprenavir, Bepridil, Cisapride, Disulfiram, and others, due to the risk of significant interactions. In some cases, metronidazole may be used with medications like Alfuzosin, Amiodarone, and others, but only under close medical supervision, as your doctor might need to adjust dosages or usage frequency.

Lastly, combining metronidazole with drugs such as Carbamazepine, Cholestyramine, Cyclosporine, and Lithium may increase the risk of side effects, though such combinations might still be necessary for your treatment. Your healthcare provider will carefully monitor and adjust your treatment plan as needed.