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When using Voquezna (vonoprazan), it is crucial to be aware of various safety information and warnings to ensure proper and safe use. Below is a summary of important precautions and risks associated with this medication:

• Cancer Risk: In rare instances, heartburn may signal a more serious stomach issue or cancer. Voquezna (vonoprazan) can mask these symptoms. If heartburn persists after treatment, consult your healthcare provider for further testing.

• Kidney Issues: Some individuals have experienced kidney inflammation after starting Voquezna (vonoprazan). Report any changes in urination, blood in urine, or general discomfort to your healthcare provider.

• Infectious Diarrhea: There is a risk of developing infectious diarrhea, especially if using Voquezna (vonoprazan) long-term, following recent hospital stays, or when taken with antibiotics.

• Bone Weakness: Long-term use of Voquezna (vonoprazan) may weaken bones and increase fracture risk. To minimize this risk, use the lowest effective dose for the shortest duration necessary.

• Severe Skin Reactions: Rare but severe skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Seek immediate medical attention if you experience flu-like symptoms or develop a painful rash.

• Low Magnesium and Vitamin B12 Levels: Prolonged use may lower magnesium and vitamin B12 levels, particularly if combined with medications like metformin. Symptoms include fatigue, headaches, and low energy. Notify your healthcare provider if these occur.

• False Positive Lab Tests: Inform your provider that you are taking Voquezna (vonoprazan) before undergoing tests for neuroendocrine tumors, as the medication can increase serum chromogranin A (CgA) levels, potentially leading to false positives. Delay testing for at least two weeks after completing treatment.

Contraindications:

• Voquezna (vonoprazan) should not be used if you are taking rilpivirine (Edurant) due to serious health risks. Always consult your healthcare provider to discuss any contraindications before starting this medication.

These warnings and precautions are critical to your health and safety. Always communicate with your healthcare provider regarding any concerns or symptoms you may experience while using this medication.

When taking this medication, you may experience some common side effects such as diarrhea, nausea, stomach inflammation, stomach pain, and indigestion. These are generally mild and should not cause undue concern. However, if they persist or become bothersome, it's advisable to consult with your healthcare provider.

Some users have also reported urinary tract infections and bloating. While these effects are less common, it's important to monitor your symptoms and seek advice if they worsen.

In rare cases, more serious side effects can occur. Serious kidney problems may manifest as bloody urine, fever, sleepiness, confusion, rash, vomiting, and fluid retention. Additionally, a severe intestinal condition linked to the bacteria C. difficile could lead to persistent diarrhea, abdominal pain, and blood or mucus in stool. Be vigilant for signs of vitamin B-12 deficiency, such as unusual weakness or numbness in the hands and feet, especially if the drug is taken over a long period.

Allergic reactions, although rare, require immediate medical attention. Symptoms can include rash, swelling, severe dizziness, or difficulty breathing. If any of these severe symptoms arise, seek urgent medical help without delay. Always monitor your health closely when starting a new medication and report any unexpected side effects to your healthcare provider.