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Please carefully read the following safety information regarding the use of rabeprazole (Aciphex) and discuss any concerns with your healthcare provider to ensure safe usage.

• Masking Severe Conditions: GERD symptoms may sometimes indicate stomach cancer. If your GERD symptoms worsen or recur after taking rabeprazole, or if you experience poor appetite, unexplained weight loss, or weakness, contact your healthcare provider immediately for further evaluation.

• Kidney Issues: Rare instances of sudden kidney inflammation have been reported with PPI use. If you notice changes in urination, nausea, weakness, fever, rash, or joint pain, seek medical advice promptly.

• Infectious Diarrhea: PPIs, including rabeprazole, may increase the risk of severe infectious diarrhea, particularly in individuals over 65, those with recent hospital or nursing home stays, or those with weakened immune systems. To minimize this risk, use the lowest effective dose for the shortest duration necessary. If you experience severe diarrhea, fever, abdominal pain, or nausea, consult your provider immediately.

• Bone Fracture Risk: There is a potential increased risk of bone fractures, especially in the hip, wrist, or spine, with prolonged or high-dose use of rabeprazole. If you have a history of bone fractures or osteoporosis, discuss your risks with your provider before starting this medication.

• Serious Skin Reactions: Though rare, serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis may occur. If you develop fever, body aches, rash, or blisters, seek emergency medical attention.

• Lupus: Rabeprazole may trigger or worsen lupus symptoms, such as joint pain or rash. If you notice these symptoms, discontinue use and contact your healthcare provider.

• Nutrient Deficiencies: Long-term use (3 years or more) of rabeprazole can result in vitamin B12 deficiency. Be alert for symptoms like dizziness, muscle weakness, pallor, fatigue, or tingling, and consult your provider if they occur.

• Drug Interactions: Rabeprazole can alter the effectiveness of other medications. It is particularly important to avoid combining rabeprazole with medications containing rilpivirine, like Edurant, as this can reduce the efficacy of the HIV treatment.

Contraindications: Do not use rabeprazole if you are taking Edurant (rilpivirine) or medications containing rilpivirine, such as Complera, due to potential serious interactions. Always consult your healthcare provider for guidance.

When using this medication, some common side effects may occur, such as pain, sore throat, passing gas, infections, and constipation. These effects are typically mild, but if they persist or worsen, it is advisable to consult your healthcare provider for further guidance.

Other side effects that have been reported include headache, belly pain, diarrhea, dry mouth, dizziness, swelling of hands and feet, and muscle or joint pain. While these are generally not severe, informing your healthcare provider if they occur is a prudent step.

There are also more serious side effects that, though rare, demand immediate medical attention. These include severe stomach pain or persistent diarrhea, which may indicate a bacterial infection. Kidney problems may manifest as changes in urination, fever, or poor appetite. Symptoms of lupus, such as joint pain or a rash that worsens with sunlight exposure, also require urgent care. Serious skin reactions, characterized by blistering, peeling, or bleeding skin, along with fever or chills, should not be ignored.

In rare cases, prolonged use of proton pump inhibitors like rabeprazole can lead to vitamin B-12 deficiency, particularly if taken daily for over three years. Be attentive to symptoms such as unusual weakness, a sore tongue, or numbness in the hands or feet. Severe allergic reactions are uncommon but may include fever, swollen lymph nodes, rash, itching, swelling of the face, severe dizziness, or trouble breathing, necessitating immediate medical help.

Always remain vigilant for any other side effects and consult your healthcare provider if you experience any unexpected symptoms during treatment.

Rabeprazole, known as Aciphex, can interact with various medications. It’s crucial to inform your healthcare provider about all the medicines and supplements you are taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products. One notable interaction is with the medication Rilpivirine, which is generally advised against.

Rabeprazole reduces stomach acid, potentially affecting the absorption and effectiveness of certain drugs. These include Ampicillin, Atazanavir, Erlotinib, levoketoconazole, nelfinavir, pazopanib, and some azole antifungals like Itraconazole, Ketoconazole, and Posaconazole. Other medications that may require dosage adjustments when taken with Rabeprazole are Methotrexate (especially in high doses), acalabrutinib, amphetamine, bosutinib, and more.

In some cases, Rabeprazole might also alter certain lab test results, leading to false readings. Always ensure that your doctors and lab personnel are aware you are using this medication.