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When taking this medication, some individuals might experience mild headaches or abdominal discomfort. These effects are generally not serious but should be discussed with your healthcare provider if they persist or worsen. More serious side effects that require immediate medical attention include swelling of the hands or feet, sudden weight gain, and symptoms indicating a low magnesium level, such as muscle spasms, irregular heartbeat, or seizures. Other concerning symptoms are signs of lupus, like a rash on the nose and cheeks or joint pain, and signs of kidney issues, such as changes in urine output or color.

In rare cases, large doses of calcium in conjunction with this medication can lead to milk-alkali syndrome, which is serious. Symptoms include dizziness, muscle aches, mood changes, vomiting, and weakness. Use of this medication can also rarely cause a severe intestinal condition due to C. difficile, characterized by persistent diarrhea, stomach pain, or blood in stools. Avoid anti-diarrhea or opioid products if these symptoms arise, as they may worsen the condition.

Long-term daily use of proton pump inhibitors may lead to vitamin B-12 deficiency, with symptoms such as unusual weakness, sore tongue, or numbness in the extremities. An allergic reaction to the medication is very rare but requires urgent medical care if symptoms like fever, rash, swollen lymph nodes, or difficulty breathing occur. Always discuss any unusual effects with your healthcare provider to ensure safety.