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This medication carries several important safety considerations and potential risks that you should be aware of before starting treatment. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns:

• Severe Allergic Reactions: There is a risk of experiencing a life-threatening allergic reaction known as anaphylaxis when using Xolair (omalizumab). Symptoms may include difficulty breathing, severe dizziness, itchy skin, and swelling of the throat or tongue. Such reactions can occur after the initial doses, but have been reported even a year into treatment. If you have a history of severe allergies to medications or foods, you are at a higher risk. Immediate medical attention is necessary if you notice symptoms such as itching, swelling (especially of the face, tongue, or throat), trouble breathing, severe dizziness, fainting, or rash/hives. If you have had an allergic reaction to omalizumab, it is crucial never to use it again.

• Asthma Management: Xolair (omalizumab) is intended to be an add-on maintenance medication for asthma and should not be used to treat an asthma attack. In case of an asthma attack, use your prescribed rescue inhaler (e.g., albuterol).

• Emergency Treatment for Allergic Reactions: This medication is not suitable for emergency treatment of severe allergic reactions. It is designed to help prevent serious allergic reactions from certain foods, but should not replace prescribed emergency treatments like epinephrine. Continue to avoid known allergens and seek immediate medical attention if a serious allergic reaction occurs.

• Common Side Effects: Some individuals may experience fever, joint pain, or a rash following a dose, typically occurring 1 to 5 days after administration. These side effects often diminish with continued use. Report any persistent or severe symptoms to your healthcare team.

• Cancer Risk: Although rare, there have been reports of cancer in individuals using Xolair (omalizumab) during clinical studies. If you or your family have a history of cancer, discuss the potential risks and benefits with your allergist.

• Vasculitis: Very rarely, symptoms related to blood vessel inflammation (vasculitis) may occur, such as intense itching, rash, breathing difficulties, tingling or numbness in extremities, and sinus pain/swelling. Report these symptoms to your allergist immediately.

• Parasitic Infections: If you are at high risk for parasitic infections, or have had such infections previously, your allergist should be informed. Xolair (omalizumab) may increase the risk of a parasitic infection, so proper testing and follow-up are necessary.

It is important to discuss all potential risks and benefits of Xolair (omalizumab) with your healthcare provider to ensure it is a suitable treatment option for you.

When taking this medication, some individuals may experience mild side effects such as itching, bruising, redness, pain, or swelling at the injection site. Headaches are relatively common and occur in about 8% of users, while joint pain affects around 8% of individuals as well. Other mild reactions include body pain, leg pain, dizziness, and fatigue, which occur less frequently. These side effects are usually mild, but if they persist or worsen, it’s important to consult a healthcare provider for further guidance.

In addition to mild side effects, there are some serious side effects that require immediate medical attention. These include symptoms such as unusual lumps, changes in skin appearance, numbness or tingling in the arms or legs, worsening shortness of breath, and coughing up blood. Other serious side effects may include muscle or joint pain, signs of infection, chest pain, unusual sweating, weakness on one side of the body, sudden changes in vision, confusion, trouble speaking, and pain, redness, or swelling of the legs. These are rare but serious, and it is crucial to seek urgent medical care if they occur.

Remember, this is not an exhaustive list of potential side effects. If you notice any other unusual effects, it is advisable to contact a healthcare professional for personalized advice and support.