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This medication carries several important safety considerations and potential risks that you should be aware of before starting treatment. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns:

• Severe Allergic Reactions: There is a risk of experiencing a life-threatening allergic reaction known as anaphylaxis when using Xolair (omalizumab). Symptoms may include difficulty breathing, severe dizziness, itchy skin, and swelling of the throat or tongue. Such reactions can occur after the initial doses, but have been reported even a year into treatment. If you have a history of severe allergies to medications or foods, you are at a higher risk. Immediate medical attention is necessary if you notice symptoms such as itching, swelling (especially of the face, tongue, or throat), trouble breathing, severe dizziness, fainting, or rash/hives. If you have had an allergic reaction to omalizumab, it is crucial never to use it again.

• Asthma Management: Xolair (omalizumab) is intended to be an add-on maintenance medication for asthma and should not be used to treat an asthma attack. In case of an asthma attack, use your prescribed rescue inhaler (e.g., albuterol).

• Emergency Treatment for Allergic Reactions: This medication is not suitable for emergency treatment of severe allergic reactions. It is designed to help prevent serious allergic reactions from certain foods, but should not replace prescribed emergency treatments like epinephrine. Continue to avoid known allergens and seek immediate medical attention if a serious allergic reaction occurs.

• Common Side Effects: Some individuals may experience fever, joint pain, or a rash following a dose, typically occurring 1 to 5 days after administration. These side effects often diminish with continued use. Report any persistent or severe symptoms to your healthcare team.

• Cancer Risk: Although rare, there have been reports of cancer in individuals using Xolair (omalizumab) during clinical studies. If you or your family have a history of cancer, discuss the potential risks and benefits with your allergist.

• Vasculitis: Very rarely, symptoms related to blood vessel inflammation (vasculitis) may occur, such as intense itching, rash, breathing difficulties, tingling or numbness in extremities, and sinus pain/swelling. Report these symptoms to your allergist immediately.

• Parasitic Infections: If you are at high risk for parasitic infections, or have had such infections previously, your allergist should be informed. Xolair (omalizumab) may increase the risk of a parasitic infection, so proper testing and follow-up are necessary.

It is important to discuss all potential risks and benefits of Xolair (omalizumab) with your healthcare provider to ensure it is a suitable treatment option for you.

Xolair (omalizumab) is a medication used to treat certain allergic conditions, including moderate to severe asthma, chronic rhinosinusitis with nasal polyps, chronic spontaneous urticaria (a type of hives), and to help prevent allergic reactions caused by certain food allergies. Understanding potential interactions with other substances is important for safe and effective use.

Drug Interactions:

Currently, there are no known significant interactions between Xolair and other medications. However, this does not guarantee that interactions do not exist. It's essential to inform your healthcare provider about all prescription and over-the-counter medications, vitamins, and supplements you are taking before starting Xolair. This comprehensive disclosure helps prevent potential interactions that may not yet be identified.

Alcohol Consumption:

There are no established interactions between Xolair and alcohol. However, both Xolair and alcohol can cause side effects such as dizziness and nausea. Consuming alcohol while on Xolair may increase the likelihood or severity of these side effects. Additionally, alcohol can weaken the immune system, potentially increasing the risk of infections, which is a concern for individuals with conditions treated by Xolair. It's advisable to discuss alcohol consumption with your doctor to determine what is safe for you during treatment.

Other Considerations:

• Vaccinations: There are no known interactions between Xolair and vaccines. However, always inform your healthcare provider about your vaccination history and any upcoming vaccines to ensure optimal care.

• Laboratory Tests: Xolair can elevate levels of immunoglobulin E (IgE) in your blood, which may persist for up to a year after stopping treatment. This elevation can affect the results of certain lab tests measuring IgE levels. Inform your healthcare provider that you are using or have used Xolair if such tests are ordered.

• Health Conditions: Certain health conditions may influence the safety and effectiveness of Xolair. For instance, if you have a history of parasitic infections, Xolair may increase your risk of such infections. Additionally, individuals with a history of cancer should discuss potential risks with their doctor, as there have been rare reports of new cancers in people treated with Xolair. Always provide a complete medical history to your healthcare provider before starting treatment.

In summary, while Xolair does not have many known interactions, it's crucial to maintain open communication with your healthcare provider about all medications, supplements, and health conditions. This proactive approach ensures the safe and effective use of Xolair in your treatment plan.