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Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), carries certain risks and requires specific precautions during use. The following information provides important safety details and guidance for those taking this medication. Consult with your healthcare provider to fully understand the benefits and potential risks associated with fenoprofen.

• Heart Risks: Fenoprofen may increase the risk of heart attack or stroke, especially with prolonged use or if you have a history of heart disease. Avoid using this medication right before or after heart bypass surgery. Discuss alternatives with your healthcare provider if you are planning such surgery.

• Gastrointestinal Bleeding: There is a risk of serious, potentially fatal bleeding in the stomach or intestines that can occur without warning. This risk is higher in older adults and those with a history of ulcers or gastrointestinal problems. Report to your provider if you experience persistent stomach pain, black or tarry stools, or vomit that resembles coffee grounds.

• Blood Pressure and Heart Failure: Fenoprofen may raise blood pressure and exacerbate symptoms of heart failure. Regular monitoring of blood pressure is advised, particularly if you have a history of high blood pressure or heart failure. Discuss the risks with your provider if you have heart failure.

• Kidney and Liver Concerns: Use of fenoprofen can impair kidney function and cause liver problems. Inform your provider if you experience symptoms such as nausea, fatigue, jaundice, or changes in urine output. Regular monitoring may be necessary for those with pre-existing kidney or liver issues.

• Allergic Reactions: Serious allergic reactions can occur, especially if you have a history of reactions to aspirin or other NSAIDs. Seek immediate medical attention for symptoms like hives, difficulty breathing, or swelling.

• Skin Reactions: Life-threatening skin reactions may develop, such as painful rashes or blisters. Discontinue use and consult your provider if these occur.

• Pregnancy Warning: Fenoprofen is not recommended during pregnancy, particularly in the third trimester, due to potential harm to the unborn baby. Discuss safer alternatives with your provider if you are pregnant or planning to become pregnant.

• Anemia Risk: The medication can increase bleeding risks, potentially leading to anemia. Be alert to symptoms such as fatigue, pale skin, or dizziness, and discuss regular blood testing with your provider.

• Vision Changes: Although rare, NSAIDs may cause vision changes. Report any blurred vision or eye irritation to an eye specialist immediately.

In case of overdose or severe side effects, seek immediate medical assistance. Always discuss with your healthcare provider to evaluate the risks and benefits of using fenoprofen in your treatment plan.

Common side effects:

• upset stomach
• headache
• sleepiness
• nausea
• dizziness
• constipation
• nervousness
• weakness
• swelling in the legs or hands

Less common but important to monitor:

• vomiting
• stomach pain
• diarrhea
• tremors
• confusion
• sweating
• itching
• rash

Serious side effects:

• liver issues
• kidney problems
• heart attack or stroke
• gastrointestinal bleeding
• serious allergic reactions
• severe skin reactions
• heart failure

Fenoprofen (Nalfon) can interact with various medications, so it's crucial to inform your healthcare provider about all the drugs and supplements you are taking, including prescribed and over-the-counter medications, as well as any vitamins or herbal supplements.

Some drugs that may interact with Fenoprofen include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Dexamethasone and Prednisone, Lithium, Methotrexate, and diuretics such as Furosemide. These interactions might necessitate a change in your treatment plan, either by adjusting the dosage or frequency of one or more medications.

Additionally, Fenoprofen can increase the risk of bleeding when combined with certain blood-thinning medications, including anti-platelet drugs like Clopidogrel and anticoagulants such as Dabigatran, Enoxaparin, and Warfarin. Therefore, it's critical to monitor for signs of bleeding if you are taking these medications together.

Many pain relievers and fever reducers, including Aspirin and NSAIDs like Ibuprofen, Ketorolac, and Naproxen, are similar to Fenoprofen and can heighten the risk of side effects when taken together. However, if your doctor has advised you to use low-dose aspirin for heart attack or stroke prevention, continue as instructed unless advised otherwise by your healthcare provider.

Lastly, Fenoprofen may affect the results of certain lab tests, such as thyroid hormone levels, potentially leading to inaccurate results. Ensure all your healthcare providers and lab technicians are aware that you are taking this medication to avoid any misinterpretation of test outcomes.