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Ibuprofen, a nonsteroidal anti-inflammatory drug, carries several important safety warnings and potential risks. It is crucial to read these warnings carefully and discuss any concerns with your healthcare provider. Below is a summary of the safety and warning information associated with ibuprofen:

• Heart Attack and Stroke Risk: Ibuprofen may increase the risk of blood clots, potentially leading to heart attacks or strokes. This risk is heightened if you have heart conditions or take ibuprofen in high doses or for prolonged periods. Avoid ibuprofen if you've recently undergone or will undergo heart surgery. Seek emergency medical help if you experience chest pain, shortness of breath, weakness on one side of the body, or difficulty speaking.

• Stomach Bleeding and Ulcers: Serious stomach issues, such as bleeding or ulcers, can occur with ibuprofen use. The risk is greater if you are older, have a history of stomach problems, or are taking medications like blood thinners. Consult your doctor if you notice symptoms like black stools, vomit resembling coffee grounds, or severe stomach pain.

• High Blood Pressure and Heart Failure: Ibuprofen can lead to fluid retention, raising blood pressure or increasing heart failure risk. If you have a history of heart issues or are on blood pressure medications, inform your provider before using ibuprofen. Report symptoms like unexplained fainting or chest pain with activity.

• Kidney Damage: Ibuprofen may impair kidney function, especially in older adults or those with existing kidney issues. Discuss your medical history with your healthcare provider, who might monitor your kidney health during treatment. Signs of kidney issues include changes in urination, fatigue, or muscle cramps.

• Liver Problems: Although rare, ibuprofen can cause severe liver damage. Immediate medical attention is needed for symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea.

• Severe Allergic Reactions: Allergic reactions to ibuprofen can be life-threatening. If you have a known allergy to aspirin or other NSAIDs, inform your doctor. If you experience hives, facial swelling, or difficulty breathing, seek medical help immediately.

• Pregnancy Risks: Ibuprofen can harm an unborn baby, especially after the 20th week of pregnancy. Consult your healthcare provider about the risks and benefits if you are pregnant or planning to become pregnant.

• Phenylketonuria (PKU) Caution: Chewable ibuprofen tablets contain phenylalanine, which can be harmful to individuals with PKU. Check with your child's healthcare provider for safer alternatives.

• Contraindications: Do not use ibuprofen if you have a history of asthma, hives, or allergic reactions to NSAIDs, or if you have recently undergone coronary artery bypass graft surgery (CABG).

Always discuss your medical history and any other medications you are taking with your healthcare provider before using ibuprofen. They can help determine if ibuprofen is safe for you and advise on appropriate dosing to minimize risks.

When taking Ibuprofen, be aware that it may interact with a variety of other medications. Notably, it can increase the risk of bleeding if used with blood-thinning medications like Clopidogrel, Dabigatran, Enoxaparin, and Warfarin, or anti-platelet drugs. Additionally, ibuprofen should not be combined with Ketorolac due to potential adverse effects.

If you are taking drugs such as ACE inhibitors (e.g., Captopril, Lisinopril), angiotensin II receptor blockers (e.g., Valsartan, Losartan), Aliskiren, Lithium, corticosteroids (e.g., Prednisone), or diuretics like Furosemide, there may be interactions that require dose adjustments or more frequent monitoring by your doctor. Ibuprofen may also interfere with the effectiveness of low-dose Aspirin used for heart attack or stroke prevention. It's important to discuss with your doctor whether adjustments to your medication regimen are needed.

For pain or fever management, consider alternatives like Acetaminophen, especially if you are on a daily aspirin regimen. If ibuprofen is necessary, consult your doctor about the appropriate timing of doses to minimize interaction with aspirin. Always inform your healthcare provider about all other medications and supplements you are taking to avoid potential interactions.