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The following safety information outlines important warnings and precautions associated with the use of everolimus (Afinitor). It is crucial to review these details and discuss any concerns with your healthcare provider.

• Lung Issues: Inform your healthcare provider immediately if you experience coughing or difficulty breathing, as everolimus (Afinitor) may cause lung inflammation. Mild symptoms may be managed with corticosteroids while continuing treatment, but severe symptoms may require discontinuation of the medication.

• Low Blood Cell Counts and Infections: There is an increased risk of infections, especially if combined with other immune-suppressing medications.

• Severe Allergic Reactions: Everolimus (Afinitor) can trigger severe allergic reactions, including anaphylaxis. Those taking ACE inhibitors, like lisinopril, may have a higher risk of angioedema, characterized by swelling of the face and tongue. Seek immediate medical attention if you experience throat tightness, trouble breathing, flushing, chest pain, or swelling of the face, airways, or tongue.

• Mouth Sores: Painful mouth ulcers may occur, typically within the first two months of treatment. Notify your provider for possible treatments, such as mouthwashes or ice chips.

• Kidney Problems: Everolimus (Afinitor) may cause kidney issues, including failure. Regular kidney function tests will be conducted before and during treatment. Report any signs of kidney problems, such as blood in urine, painful urination, or changes in urine color or clarity, to your provider immediately.

• Increased Blood Sugar and Lipid Levels: This medication can elevate blood sugar, cholesterol, and triglycerides. Your provider will monitor these levels before and during treatment. If you have diabetes, expect more frequent blood sugar checks. Difficulty in managing these levels may lead to discontinuation of the medication.

• Radiation Therapy Sensitivity: Everolimus (Afinitor) can cause inflammation in radiation-treated areas and increase radiation sensitivity. This applies to radiation received before, during, or after treatment.

• Pregnancy and Fertility Risks: Everolimus (Afinitor) may harm an unborn baby based on animal studies. Both males and females should use effective birth control during treatment and continue for 8 weeks (females) or 4 weeks (males) after treatment. Notify your provider if pregnancy occurs.

Contraindications: Do not use everolimus (Afinitor) if you have an allergy to it or other rapamycins, such as sirolimus or temsirolimus. Discuss any potential contraindications with your healthcare provider.

Taking this medication may lead to some common side effects, which are generally mild but should still be monitored. These include diarrhea, nausea, vomiting, decreased appetite, weight loss, changes in taste, nosebleeds, dry skin, dizziness, headache, and a mild rash. Hair loss might occur temporarily, with normal growth resuming after treatment ends. Mouth sores or pain can also develop, and it's advisable to rinse your mouth with a mixture of cool water and baking soda or salt to alleviate discomfort.

It's important to be aware of more serious side effects that, although rare, require immediate medical attention. These include significant swelling in the hands, ankles, or feet, persistent bleeding or bruising, extreme fatigue, and mood changes such as anxiety or aggression. Serious infections may manifest as persistent sore throats, fevers, chills, or coughs. Any difficulty breathing, chest pain, or severe allergic reactions, including rash or swelling of the face and throat, should prompt urgent medical care.

This medication can also affect blood sugar and cholesterol levels, potentially exacerbating diabetes or requiring adjustments to your diet and medications. It may rarely cause severe kidney, liver, or lung problems, so any changes in urine output, jaundice, or shortness of breath should be reported immediately. Additionally, there's a risk of a rare brain infection, indicated by symptoms like confusion, seizures, or vision changes, which necessitates prompt medical attention.

If you notice any other unexplained effects, it’s crucial to consult with your healthcare provider. Although the chance of serious side effects may be low, staying informed and vigilant can help manage any potential risks.

Everolimus (Afinitor) can interact with various medications and supplements, impacting how it functions and possibly increasing the risk of side effects. It's crucial to inform your healthcare provider about all medications and supplements you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal products.

Certain medications that can interact with Everolimus include:

1. Immune System Suppressants: Drugs like natalizumab and rituximab may further weaken your immune system, increasing the risk of infections.

2. ACE Inhibitors: Medications such as Captopril, Lisinopril, and others might require dosage adjustments when used with Everolimus.

3. Drugs Affecting Everolimus Removal: Some medications can alter the breakdown and removal of Everolimus from your body, potentially affecting its efficacy. This includes azole antifungals (Itraconazole, Ketoconazole), cobicistat, macrolide antibiotics (Clarithromycin, Erythromycin), Nefazodone, and HIV protease inhibitors (Atazanavir, Ritonavir). Additionally, herbal supplements like St. John's wort and antibiotics like telithromycin can also have an impact.

In some cases, your doctor might advise against using Everolimus with certain drugs or adjust the dosages of one or both medications to mitigate interactions. Always coordinate closely with your healthcare provider to ensure safe and effective use of Everolimus.