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Everolimus is an immunosuppressant medication that comes with several important safety considerations. It is crucial to understand potential risks and necessary precautions while using this drug. Below are key safety warnings:

• Cancer Risk: Long-term use of everolimus may increase your risk of developing certain cancers, including lymphoma and skin cancer. Protect your skin by minimizing sun exposure, using sunscreen, and wearing protective clothing. Report any unusual skin changes or growths to your healthcare provider immediately.

• Infection Risk: Everolimus lowers your immune system's ability to fight infections, making you more susceptible to serious or potentially fatal infections. Be vigilant for symptoms such as persistent sore throats, fevers, chills, or coughs, and inform your healthcare provider if they occur.

• Blood Clots in Transplants: The use of everolimus can increase the risk of blood clots in the vessels of transplanted kidneys or livers, particularly within the first 30 days post-surgery. Notify your doctor if you experience symptoms such as nausea, vomiting, groin pain, lower back or abdominal pain, blood in the urine, or a significant decrease in urine output.

• Kidney Damage: When taken with other anti-rejection drugs like cyclosporine or tacrolimus, everolimus can harm your kidneys. Your doctor will adjust doses and monitor kidney function through regular lab tests to maintain safety.

• Allergic Reactions: Everolimus can cause angioedema, a severe swelling of the face, lips, or throat, especially when combined with ACE inhibitors. Seek immediate medical attention if you experience swelling that affects breathing or swallowing.

• Wound Healing and Fluid Build-Up: This medication may slow down wound healing and increase the risk of infection or the incision opening. Some cases may require additional surgical intervention.

• Lung Issues: Everolimus is associated with interstitial lung disease, causing lung inflammation or scarring. Report any breathing difficulties, cough, chest pain, or wheezing to your healthcare provider promptly.

• Elevated Cholesterol and Triglycerides: This medication can raise cholesterol and triglyceride levels. Your healthcare provider will monitor these levels and may suggest dietary changes or medication if necessary.

• Diabetes Risk: Everolimus may increase the likelihood of developing diabetes after a transplant. Report symptoms like increased thirst, hunger, frequent urination, blurred vision, or fatigue to your healthcare provider.

• Pregnancy and Fertility Concerns: Everolimus can harm an unborn baby. Individuals who can become pregnant should use effective birth control during treatment and for 8 weeks after stopping the medication. Discuss potential risks if pregnant or planning a pregnancy with your healthcare provider.

• Vaccine Interactions: Avoid live vaccines while taking everolimus, as the medication may alter immune responses. Consult your healthcare provider to ensure any necessary vaccines are safe.

Contraindications:

• Do not use everolimus if you have an allergy to sirolimus.

This safety information is critical for ensuring the safe use of everolimus. Always consult your healthcare provider for personalized advice and report any concerning symptoms promptly.

When taking this medication, some individuals may experience common side effects such as constipation, nausea, and headaches. These symptoms are generally mild, but if they persist or worsen, it is advisable to consult your healthcare provider. Swelling in the arms and legs, high blood pressure, and urinary tract infections have also been reported, with high cholesterol and anemia being other potential effects. These side effects are often manageable with medical guidance.

There are more serious side effects that require immediate medical attention. These include severe diarrhea, vomiting, and stomach pain. If you experience fever, fatigue, or upper respiratory issues, it is crucial to seek urgent medical care. Muscle and back pain, along with trouble sleeping, have also been noted as severe reactions.

Rarely, this medication can cause very serious health issues. It has been associated with potentially life-threatening lung problems, marked by shortness of breath and chest pain. Additionally, there is a risk of a rare brain infection known as progressive multifocal leukoencephalopathy (PML), which can lead to symptoms such as confusion, difficulty with coordination, and vision changes. If you notice any of these symptoms, it is vital to get medical help immediately.

While the risk of a severe allergic reaction is low, it is important to be aware of symptoms like rash, itching, severe dizziness, and trouble breathing, which require prompt medical attention. Lastly, the medication may affect cholesterol, triglyceride, and blood sugar levels, necessitating periodic checks and possibly additional medication to manage these changes. Always consult your healthcare provider if you have concerns or notice any other side effects.

Everolimus (Zortress) can interact with a variety of medications and supplements, so it's important to inform your healthcare provider about everything you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Some interactions can affect how everolimus is processed in your body, potentially impacting its effectiveness.

Certain medications that may interact with everolimus include those that suppress the immune system or heighten the risk of infection, such as natalizumab and rituximab. Additionally, ACE inhibitors like captopril and lisinopril may interact with this drug.

Other drugs can alter how everolimus is eliminated from your system. Examples include azole antifungals like itraconazole and ketoconazole, cobicistat, macrolide antibiotics such as clarithromycin and erythromycin, HIV protease inhibitors like atazanavir, rifamycins such as rifabutin and rifampin, ritonavir, St. John's wort, and telithromycin.

It is generally not advisable to use everolimus with ritonavir. However, if your doctor decides that the combination is necessary, they may adjust the dosages or frequency of one or both medications. Always consult your healthcare provider before making any changes to your medication regimen.