
Ritonavir Coupons & Savings Card – Discount Prices from $32.64
Generic for: Norvir
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100MG, Ritonavir (30 Tablets)
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CVS
$32.64
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Rite Aid
$32.69
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Albertsons
$40.57
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Walgreens
$42.60
COUPON PRICERitonavir savings card
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CVS
$32.64
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LHB497EF75
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Ritonavir dosage forms
Dosage | Quantity | Price from | Per unit |
---|---|---|---|
100MG | 30 Tablets | $32.64 | $1.09 |
Our price history data is based on aggregated prescription data collected from participating pharmacies in America. Our prescription data updates daily to reflect the latest price changes. If you notice a missing data point, it means there wasn't sufficient data available to generate a monetary value for that date.
Ritonavir Warnings
Ritonavir (Norvir) is associated with several important safety considerations that patients and healthcare professionals should be aware of. Please review the following points carefully and discuss any concerns with your healthcare provider.
Interactions with Other Medications: Ritonavir may interact with various drugs, potentially leading to severe reactions. Certain medications can hinder the body's ability to eliminate ritonavir, impacting its efficacy and increasing the risk of side effects. Consult your healthcare provider or pharmacist to ensure compatibility with other medications you are taking.
Liver Issues: Ritonavir can cause serious liver problems, particularly within the first three months of treatment. Regular blood tests will be conducted to monitor liver function. Seek immediate medical attention if symptoms of liver damage occur, such as drowsiness, nausea, appetite loss, light-colored stool, upper right stomach pain, jaundice, or dark urine. Those with hepatitis B or C or a history of liver problems are at increased risk.
Pancreatitis Risk: Although rare, ritonavir may lead to inflammation of the pancreas (pancreatitis), especially in individuals with high triglycerides or advanced HIV. If symptoms like upper stomach pain, fever, nausea, or vomiting arise, discontinue use and contact your healthcare provider immediately.
Heart Rhythm Concerns: Ritonavir can affect heart rhythm (PR prolongation), which can be life-threatening. Increased risk is associated with imbalanced electrolytes, existing heart rhythm issues, or concurrent use of medications affecting heart rhythm. Seek urgent medical care if you experience palpitations, difficulty breathing, chest pain, or dizziness.
Severe Skin and Allergic Reactions: Ritonavir may cause mild to moderate rashes; however, severe reactions warrant immediate medical attention. Discontinue use if a severe rash is accompanied by fever, discomfort, muscle or joint pain, mouth sores, blisters, or facial swelling.
High Blood Sugar and Cholesterol Levels: Ritonavir can elevate blood sugar and cholesterol levels, especially when taken with certain HIV medications. Patients with diabetes may need dosage adjustments of their diabetic medications. Monitor blood sugar and cholesterol levels, and inform your provider of any significant changes or history of these conditions.
Body Fat Changes: Some individuals may experience altered body fat distribution, such as fat accumulation in certain areas or loss in others. Report any noticeable changes to your healthcare provider.
Overactive Immune System: Combination antiretroviral therapy, including ritonavir, might result in immune reconstitution syndrome, where the immune system becomes excessively active. Report any new symptoms, such as fever, pain, hair loss, bulging eyes, or sweating, to your healthcare provider.
Bleeding Risk: Individuals with a history of bleeding disorders, like hemophilia, may experience increased bleeding. Inform your provider if unexpected or difficult-to-stop bleeding occurs.
Potential Harm to Newborns: The oral solution of ritonavir contains ethanol and propylene glycol, which could be hazardous to prematurely born infants. Seek immediate medical attention if symptoms such as breathing difficulties, dizziness, or nausea arise.
Contraindications: Ritonavir should not be used with certain medications metabolized by the liver protein CYP3A4, including alfuzosin, dronedarone, lovastatin, and simvastatin, due to potential serious health risks. Consult your healthcare provider if you are taking these medications.
These guidelines are crucial for ensuring the safe use of ritonavir. Always communicate openly with your healthcare provider regarding any medications you are taking or health conditions you may have.
Ritonavir Side Effects
Common side effects:
- Diarrhea
- Nausea
- Vomiting
- Dizziness
- Feeling tired or weak
- Heartburn
- Stomach pain
- Changes in taste
- Tingling sensation in the mouth
- Increased cholesterol levels
- Rash
- Back and joint pain
- Coughing
- Throat pain
- Excessive gas
- Blurry vision
- Swelling
- Muscle pain
- Spinning sensation
- Frequent urination
Sensation of cold in hands and feet
Serious side effects:
- Severe allergic reactions (facial swelling, hives, trouble breathing)
- Serious liver problems (persistent nausea, vomiting, abdominal pain, yellowing of the skin or eyes, dark urine)
- Abnormal heart rhythms (chest pain, feeling faint)
Ritonavir Interactions
Ritonavir is known to interact with many other medications. It can alter how certain drugs are processed in your body, either slowing down or speeding up their removal, which can affect their effectiveness. Medications that may interact with ritonavir include cobicistat, Disulfiram, and Orlistat. Specific drugs that might be impacted by this interaction include alfuzosin, certain heart rhythm medications like Amiodarone and Flecainide, azole antifungals such as Voriconazole, some benzodiazepines like Midazolam and Triazolam, blood thinners including rivaroxaban and Warfarin, Eletriptan, medications for erectile dysfunction or pulmonary hypertension like avanafil and Sildenafil, ergot alkaloids, Lurasidone, certain opioid pain relievers such as Fentanyl, Pimozide, ranolazine, salmeterol, and statin drugs like Simvastatin.
Additionally, other drugs can influence how ritonavir is processed in your body, possibly affecting its effectiveness. These include apalutamide, Rifampin, and St. John's wort. It's important to note that ritonavir may reduce the effectiveness of hormonal birth control methods such as pills, patches, or rings, potentially leading to pregnancy. Consider discussing alternative or additional contraceptive methods with your healthcare provider. Additionally, inform your doctor if you experience unusual spotting or breakthrough bleeding, as these could indicate that your birth control is not functioning properly.
What does the drug ritonavir do?
Ritonavir is an antiretroviral medication used to treat and manage HIV/AIDS. It works by inhibiting the protease enzyme, which is essential for the replication of the virus. Ritonavir is often used in combination with other antiretroviral drugs to enhance their effectiveness, as it can boost the levels of these drugs in the body by inhibiting certain liver enzymes.
What does ritonavir do in Paxlovid?
Ritonavir in Paxlovid acts as a pharmacokinetic enhancer. It inhibits the enzyme CYP3A4, which slows the metabolism of nirmatrelvir, the other component of Paxlovid. This allows nirmatrelvir to remain in the body longer at higher concentrations, enhancing its antiviral effectiveness against the virus.
What drugs should not be taken with ritonavir?
Ritonavir can interact with several medications, leading to potentially serious effects. Drugs that should generally be avoided or used with caution when taking ritonavir include:1. Certain antiarrhythmics, such as amiodarone and flecainide.2. Ergot derivatives, like ergotamine and dihydroergotamine.3. Specific sedatives and hypnotics, including midazolam and triazolam.4. Some statins, particularly lovastatin and simvastatin.5. Certain antipsychotics, such as lurasidone and pimozide.6. Some anticonvulsants, like carbamazepine and phenobarbital.7. St. John's Wort, a herbal supplement.It is important for individuals to consult with their healthcare provider for a comprehensive list and personalized advice, as this is not an exhaustive list and other interactions may exist.
Why is ritonavir not used alone?
Ritonavir is not used alone because it primarily functions as a pharmacokinetic enhancer rather than a standalone antiretroviral agent. Its main role is to boost the effectiveness of other protease inhibitors by inhibiting the enzyme CYP3A4, which increases the plasma concentration of these drugs, thereby enhancing their efficacy. Using ritonavir alone would not provide sufficient antiviral activity to effectively manage HIV infection.
Why are ritonavir and zidovudine taken together?
Ritonavir and zidovudine are taken together as part of combination antiretroviral therapy to treat HIV infection. Ritonavir acts as a protease inhibitor, while zidovudine is a nucleoside reverse transcriptase inhibitor. Using them together helps to enhance the effectiveness of the treatment by targeting different stages of the HIV life cycle, reducing the viral load, and slowing the progression of the disease. This combination also helps in preventing the development of drug resistance.