Nefazodone

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Nefazodone is prescribed for the treatment of depression. It is generally considered only after other medications have been tried, due to the potential risk of serious liver damage. Nefazodone functions by increasing the levels of serotonin and norepinephrine in the brain, which are natural substances that help improve mood. This medication is not associated with significant weight changes and typically does not cause withdrawal symptoms. It is available only as a generic, as the brand name version, Serzone, is no longer on the market. Common side effects can include headache, dry mouth, nausea, and drowsiness. Always consult with your healthcare provider before starting or stopping any medication.
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100MG, Nefazodone (30 Tablets)

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Nefazodone Warnings

This document outlines crucial safety and warning information regarding the use of nefazodone. It is essential to understand the potential risks and consult your healthcare provider if you have any concerns.

  • Worsening Depression and Suicidal Thoughts: Nefazodone, like other antidepressants, may increase the risk of worsening depression and suicidal thoughts, particularly in individuals under 24 years of age. This risk is most significant during the initial months of treatment or following dosage adjustments. If you or someone you care for experiences mood changes, such as anxiety, irritability, panic attacks, aggression, or suicidal ideation, contact your healthcare provider immediately. The National Suicide Prevention Lifeline is available 24/7 at 988. Risk factors include a personal or family history of mental health conditions or suicide.

  • Liver Issues: Nefazodone can cause severe liver damage, including failure, which may necessitate a transplant or result in death. It should not be used if you have existing liver problems. Prior to starting treatment, your healthcare provider may conduct liver function tests. Be alert for symptoms of liver damage such as jaundice, abdominal pain, loss of appetite, dark urine, nausea, vomiting, fatigue, or confusion, and contact your healthcare provider if these occur. Risk factors include a history of liver issues.

  • Bipolar Disorder: Depression might be an early sign of bipolar disorder, characterized by mood fluctuations between depression and mania. Nefazodone should not be used alone for treating bipolar depression due to the risk of triggering mania. Consult your healthcare provider for a comprehensive assessment if you have a history of mood disorders.

  • Eye Conditions: Nefazodone can cause pupil dilation, potentially leading to angle-closure glaucoma, a condition that increases eye pressure and may require surgical intervention. Inform your healthcare provider if you have concerns about eye health.

  • Orthostatic Hypotension: Sudden changes in posture after sitting or lying down can cause a drop in blood pressure, leading to dizziness and falls. Rise slowly to mitigate this risk, especially if you are on blood pressure medications. Risk factors include a history of cardiovascular issues.

  • Seizures: Use nefazodone cautiously if you have a history of seizures. Should you experience any seizure symptoms, such as convulsions, stiffness, or unconsciousness, seek emergency medical help immediately. Risk factors include a history of seizures or concurrent use of other seizure-inducing medications.

  • Heart Conditions: Individuals with a history of heart disease or low heart rate should use nefazodone cautiously and may require close monitoring. Discuss your heart health with your healthcare provider before beginning treatment. Risk factors include existing heart conditions or medications affecting heart rate.

Contraindications: Avoid using nefazodone if you have previously experienced liver problems while taking it, or if you are using medications such as carbamazepine, triazolam, terfenadine, astemizole, cisapride, or pimozide. Always consult your healthcare provider if these conditions apply to you.

Nefazodone Side Effects

Common side effects:

  • Headaches
  • Sleepiness
  • Dry mouth
  • Nausea
  • Dizziness
  • Constipation
  • Trouble sleeping
  • Weakness
  • Lightheadedness
  • Blurred vision
  • Indigestion

Less common but important to monitor:

  • Diarrhea
  • Infections
  • Confusion
  • Changes in vision
  • Sore throat
  • Increased appetite
  • Memory issues
  • Low blood pressure when standing up
  • Feeling flushed or warm
  • Burning or tingling sensation in the arms or legs

Serious side effects:

  • Severe allergic reactions (hives, difficulty breathing, swelling of the face or throat)
  • Liver problems (jaundice, abdominal pain, dark urine)
  • Seizures
  • Suicidal thinking or behavior

Nefazodone Interactions

Some products that may interact with this drug include: carbamazepine, eplerenone, ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine), ivabradine, lurasidone, pimozide, triazolam, alpha blockers (such as terazosin), digoxin, fluoxetine, medications for high blood pressure, other antidepressants (including trazodone, SSRIs such as fluoxetine), other drugs that can cause bleeding/bruising (for example, anticoagulants such as heparin or warfarin, antiplatelet drugs including NSAIDs such as ibuprofen). Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and 1 week after treatment with this medication. Ask your doctor when to start or stop taking this medication. Avoid taking eletriptan within 72 hours of taking this medication. This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include buspirone, dasatinib, domperidone, fentanyl, regorafenib, sunitinib, tacrolimus, "statin" cholesterol drugs (such as simvastatin, lovastatin, atorvastatin), certain benzodiazepines (such as alprazolam) among others. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) that may increase your risk for bleeding if taken together with this drug. However, if your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.
Nefazodone FAQs
Why is nefazodone no longer commonly used?

Nefazodone is no longer commonly used primarily due to concerns about its potential to cause serious liver damage, including liver failure. This risk led to a significant decline in its use and availability, as well as the withdrawal of the drug from the market in several countries. While it may still be available in some regions, its use is generally limited to cases where other treatments are not suitable, and it requires careful monitoring of liver function.

Nefazodone and trazodone are not the same, although they are both antidepressants. They belong to the same class of medications known as serotonin modulators, but they have different chemical structures and pharmacological profiles. Each medication may have different side effects and interactions, so it is important for a healthcare provider to determine which is more appropriate for a patient's specific condition.

Nefazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).

Nefazodone is primarily prescribed as an antidepressant, but it may also help alleviate symptoms of anxiety in some patients. However, it is not typically the first-line treatment for anxiety disorders. It is important for patients to consult with their healthcare provider to determine the most appropriate medication for their specific condition.

Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI). It is primarily used as an antidepressant and for its sedative properties.