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This communication outlines essential safety information and warnings associated with the use of this medication. It is crucial to understand these risks and precautions, and to seek guidance from your healthcare provider if you have any questions or concerns.

• Severe Allergic and Skin Reactions: There is a possibility of severe allergic responses to amoxicillin (Amoxil), including potentially life-threatening reactions such as facial swelling and anaphylaxis, which may involve throat closure. If you have a known allergy to antibiotics, inform your healthcare provider. Seek immediate medical attention if you experience symptoms such as hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after taking amoxicillin. Individuals with a penicillin allergy or those currently suffering from a mononucleosis infection are at higher risk.

• Diarrhea from Clostridioides Difficile Infection: The use of antibiotics, including amoxicillin, increases the risk of C. difficile infection, which can cause severe diarrhea. This occurs due to alterations in the normal bacterial flora of the stomach and intestines, leading to an overgrowth of C. diff. Symptoms of this infection include rapid heart rate, foul-smelling diarrhea, fever, nausea, bloody stools, or frequent bowel movements (up to 15 times per day). This condition is a medical emergency, requiring immediate attention and testing for C. diff infection, followed by appropriate treatment.

• Development of Drug-Resistant Bacteria: Amoxicillin should only be used for the infections and duration prescribed by your healthcare provider. Incorrect use, such as taking it for unapproved illnesses or not following the prescribed duration, can lead to the development of drug-resistant bacteria. This increases the risk of severe, hard-to-treat infections.

Contraindications: Avoid using this medication if you have any of the following conditions, as it may pose significant health risks. Consult with your healthcare provider if any of these apply to you:

• Severe allergy to penicillins or beta-lactam antibiotics, such as cephalexin (Keflex).

By understanding these warnings and contraindications, you can ensure safer use of this medication. Always consult your healthcare provider for personalized medical advice.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Rash
• Headaches
• Changes in taste

Less common but important to monitor:

• Oral thrush
• New vaginal yeast infection

Serious side effects:

• Signs of liver disease (persistent nausea or vomiting, loss of appetite, stomach pain, yellowing of the eyes or skin, dark urine)
• Severe intestinal condition caused by C. difficile (persistent diarrhea, abdominal pain, blood/mucus in stool)
• Allergic reaction (persistent fever, swelling of lymph nodes, rash, itching, swelling of face/tongue/throat, severe dizziness, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Methotrexate
• Warfarin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Chlortetracycline
• Acenocoumarol
• Khat
• Probenecid