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This safety information outlines crucial warnings and precautions associated with the use of ampicillin. It is essential to review these details thoroughly and discuss any concerns with your healthcare provider.

• Severe Allergic Reactions: Ampicillin may cause serious allergic reactions, including conditions like facial swelling and anaphylaxis, which can be life-threatening. Notify your healthcare provider if you have a known allergy to antibiotics, particularly penicillin. Seek immediate medical attention if you experience symptoms such as hives, skin rash, swelling of the lips or tongue, or difficulty breathing following ampicillin use.

• Infectious Diarrhea: Using antibiotics, such as ampicillin, can increase your risk of infection with Clostridioides difficile (C. diff), leading to potentially severe diarrhea. This occurs due to changes in the normal bacterial flora in the stomach and intestines. C. diff infection symptoms include rapid heart rate, foul-smelling diarrhea, fever, nausea, bloody stools, or frequent bowel movements. If you experience these symptoms, seek urgent medical care to be tested and treated for C. diff infection.

• Development of Drug-Resistant Bacteria: Your healthcare professional will ensure ampicillin is used appropriately for the specific infection and duration. Deviating from prescribed usage can contribute to the development of drug-resistant bacteria, increasing the risk of severe infections that are challenging to treat.

• Reduced Effectiveness of Birth Control Pills: Ampicillin may decrease the effectiveness of birth control pills, potentially leading to unintended pregnancy and breakthrough bleeding. If you rely on oral contraceptives, consider using an additional barrier method, such as condoms or diaphragms, while taking ampicillin.

Contraindications: Avoid using ampicillin if you have a severe allergy to penicillins or other beta-lactam antibiotics. Consult your healthcare provider if this applies to you before starting the medication.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Rash

Less common but important to monitor:

• Sores in the mouth or on the tongue
• Oral thrush
• Vaginal yeast infection

Serious side effects:

• Easy bruising or bleeding
• Symptoms of liver disease
• Severe intestinal condition caused by C. difficile
• Allergic reactions

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Methotrexate
• Tetracyclines