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When considering the use of delafloxacin, a type of fluoroquinolone antibiotic, it is crucial to be aware of several potential risks and safety precautions. Please review the following information and consult with your healthcare provider if you have any concerns or questions:

• Tendon Damage: Delafloxacin can cause serious tendon issues, including tendonitis and tendon rupture, which can occur during or even months after treatment. These issues are more common in individuals over 60, those taking corticosteroids, or individuals with kidney, heart, or lung transplants. If you experience any pain or swelling in your joints or muscles, stop using the medication and seek medical attention immediately.

• Peripheral Neuropathy: This medication may increase the risk of peripheral neuropathy, leading to pain, burning, tingling, numbness, or weakness in the limbs. If you notice these symptoms, discontinue use and contact your healthcare provider as these effects can become permanent. Inform your provider if you have a history of peripheral neuropathy.

• Central Nervous System Effects: Delafloxacin may cause psychiatric effects such as hallucinations, depression, or suicidal thoughts, and increase the risk of seizures, dizziness, or tremors. Notify your provider immediately if you experience any of these symptoms. Those with a history of CNS conditions should discuss risks with their provider.

• Myasthenia Gravis Worsening: If you have myasthenia gravis, this medication may exacerbate muscle weakness and breathing difficulties. Discuss alternative treatments with your healthcare provider if you are affected by this condition.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, may occur. Symptoms can include swelling, shortness of breath, and skin rash. Seek emergency medical help if these symptoms present. Inform your provider about any past allergic reactions to fluoroquinolones.

• Severe Diarrhea: Delafloxacin can alter gut bacteria, leading to severe diarrhea from a C. diff infection, which may occur even months after stopping the medication. Contact your healthcare provider if you experience persistent diarrhea, stomach pain, or fever.

• Blood Vessel Injury: This medication may increase the risk of aortic aneurysm or dissection. If you experience sudden, severe pain, particularly in the back, chest, or abdomen, seek emergency care immediately. Inform your provider if you have a history of such conditions.

• Drug-Resistant Bacteria: Using delafloxacin without a bacterial infection can lead to the development of drug-resistant bacteria. It is important to only use antibiotics when necessary.

• Blood Sugar Changes: This drug may cause fluctuations in blood sugar levels. If you have diabetes, monitor your blood sugar levels closely and report any symptoms of low blood sugar to your provider.

In case of overdose, seek immediate medical assistance. Always discuss the potential benefits and risks with your healthcare provider before starting treatment with delafloxacin.

When taking this medication, some common side effects you might experience include nausea, diarrhea, dizziness, lightheadedness, headache, and vomiting. These side effects are generally mild, but if they persist or worsen, it is important to consult your healthcare provider. Additionally, some individuals may notice higher levels of liver enzymes.

There are other side effects that have been reported by users, although they occur less frequently. These include changes in blood pressure or heart rate, fluctuations in blood sugar levels, insomnia, abnormal dreams, seizures, and alterations in hearing or vision. Some patients may also encounter liver or kidney issues or anemia. If you experience any of these, particularly if they are severe, contact your healthcare professional.

Rare but serious side effects require immediate medical attention. These include a condition called Clostridioides difficile-associated diarrhea, characterized by severe abdominal cramps, persistent diarrhea, and fever. There is also a risk of tendonitis and tendon rupture, which may cause pain and swelling in joints like the ankle or shoulder. Aortic aneurysm and dissection, marked by sudden severe pain in the back, chest, or abdomen, is another serious concern. Lastly, although very rare, severe allergic reactions can occur, with symptoms like throat swelling, skin rash, facial swelling, and difficulty breathing. If any of these symptoms arise, seek urgent medical help immediately.