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The following safety information outlines important warnings concerning the use of minocycline. It is crucial to review these details and discuss any concerns with your healthcare provider.

• Risk to Unborn Babies: Minocycline may adversely affect unborn babies, potentially leading to abnormal bone development. It is advised to avoid this medication if you are planning to have a child. Additionally, minocycline can reduce the effectiveness of certain birth control pills, so an alternative contraceptive method is recommended during treatment. Should pregnancy occur while taking minocycline, discontinue use immediately and contact your healthcare provider.

• Dental Discoloration in Children: Tetracycline antibiotics, such as minocycline, can cause permanent yellow, gray, or brown discoloration of teeth in young children and unborn babies if taken during the latter half of pregnancy. This side effect may also result in weakened tooth enamel. The risk increases with prolonged or repeated use of minocycline, and is particularly significant for children under the age of 8 and pregnant women in their second and third trimesters.

• Infectious Diarrhea: Minocycline, like other antibiotics, can lead to Clostridium difficile-associated diarrhea, which might result in serious dehydration. Symptoms include watery stools, fever, stomach pain, and loss of appetite. Seek immediate medical attention if these symptoms develop, particularly if you have a history of prolonged antibiotic use or recent hospitalization.

• Severe Allergic and Skin Reactions: Rarely, minocycline can trigger severe allergic reactions or skin conditions. If you experience breathing difficulties, swelling, rash, blisters, or sores in your mouth, seek emergency medical assistance.

• Kidney and Liver Damage: Minocycline may cause kidney or liver issues, potentially leading to failure. Symptoms to watch for include dark urine, changes in urination, abdominal pain, or jaundice. Those with pre-existing kidney or liver conditions should be particularly cautious and consult their healthcare provider if symptoms arise.

• Increased Brain Pressure: Some users of tetracycline antibiotics have reported raised intracranial pressure, especially when combined with isotretinoin. Symptoms include headaches and vision changes. Contact your healthcare provider immediately if you experience these symptoms, as they may lead to permanent vision issues.

• Skin and Tissue Darkening: Minocycline can cause darkening of the skin, nails, and other body tissues. Though generally not harmful, consult your healthcare provider if you notice these changes.

• New Infections: Long-term use of minocycline may result in new infections resistant to the drug. If symptoms persist or new symptoms develop, contact your healthcare provider.

• Autoimmune Disorders: Prolonged use of minocycline, particularly for acne, may be associated with autoimmune disorders, presenting as fever, rash, joint pain, or general discomfort. Discontinue use and consult your healthcare provider if these symptoms occur.

There are no specific contraindications listed for minocycline use, but it is important to follow all prescribed guidelines and consult your healthcare provider for personalized advice.

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Lightheadedness
• Dizziness
• Headaches
• Fatigue
• Itching

Less common but important to monitor:

• Drowsiness
• Joint or muscle pain
• Spinning sensation
• General discomfort
• Changes in mood
• Dry mouth
• Ringing in the ears
• Oral thrush
• New yeast infection

Serious side effects:

• Difficulty swallowing
• Hearing changes
• Joint stiffness
• Signs of kidney or liver problems
• Unusual tooth or skin discoloration
• Intracranial hypertension
• C. difficile-associated diarrhea
• Severe allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Acitretin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amoxicillin
• Ampicillin
• Atazanavir
• Bacampicillin
• Bexarotene
• Cholera Vaccine, Live
• Cloxacillin
• Desogestrel
• Dicloxacillin
• Dienogest
• Digoxin
• Drospirenone
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Etretinate
• Gestodene
• Isotretinoin
• Levonorgestrel
• Mestranol
• Methicillin
• Methoxyflurane
• Nafcillin
• Nomegestrol
• Norethindrone
• Norgestimate
• Norgestrel
• Oxacillin
• Penicillin G
• Penicillin G Benzathine
• Penicillin G Procaine
• Penicillin V
• Piperacillin
• Pivampicillin
• Porfimer
• Sultamicillin
• Temocillin
• Tretinoin

Interactions with low risk that usually do not require a change in therapy:

• Aluminum Carbonate, Basic
• Aluminum Hydroxide
• Aluminum Phosphate
• Aminolevulinic Acid
• Calcium
• Dihydroxyaluminum Aminoacetate
• Dihydroxyaluminum Sodium Carbonate
• Iron
• Magaldrate
• Magnesium Carbonate
• Magnesium Hydroxide
• Magnesium Oxide
• Magnesium Trisilicate
• Vitamin A