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This document outlines crucial safety information and warnings regarding the use of ciprofloxacin (Ciloxan). It is important to review these details carefully and discuss any concerns with your healthcare provider.

• Application Site: Ciprofloxacin (Ciloxan) should be applied only to the affected eye's surface. Avoid contact with the mouth, nose, or any other body parts.

• Allergic Reactions: Individuals with a known allergy to fluoroquinolone antibiotics, such as ciprofloxacin, may experience severe allergic reactions, including difficulty breathing, rashes, and swelling of the face, mouth, or throat. Prior to starting treatment, inform your healthcare provider if you've had any allergic reactions to antibiotics. Seek immediate medical assistance if you encounter any allergic symptoms during treatment.

• Risk of New Eye Infections: Prolonged use of ciprofloxacin (Ciloxan) can increase the risk of secondary eye infections, including fungal infections. If you notice eye pain, redness, blurred vision, light sensitivity, or watery discharge, or if symptoms do not improve after a few days, consult your healthcare provider as these may indicate a new infection.

• White Substance on Eye Surface: Some patients using ciprofloxacin (Ciloxan) for corneal ulcers have reported a white substance forming over the ulcer area. These white crystals generally appear within 24 hours to a week after starting treatment and typically resolve without affecting the healing process. However, if the white substance causes discomfort or worsens vision, notify your healthcare provider.

• Contraindications: Do not use ciprofloxacin (Ciloxan) if you have an allergy to quinolone antibiotics, as this could pose serious health risks. Always discuss your medical history with your healthcare provider before beginning treatment.

When using Ciloxan (ciprofloxacin ophthalmic), it's important to be aware of potential interactions with other substances:

Antacids and Mineral Supplements: Products containing magnesium, aluminum, calcium, iron, or zinc can interfere with the absorption of ciprofloxacin when taken orally, reducing its effectiveness. To minimize this interaction, it's recommended to take ciprofloxacin at least two hours before or six hours after consuming such products.

Dairy Products and Calcium-Fortified Foods: Consuming dairy products or calcium-fortified juices alone can decrease the absorption of oral ciprofloxacin. However, these can be included as part of a meal when taking the medication.

Caffeine: Ciprofloxacin can slow the elimination of caffeine from the body, potentially intensifying caffeine-related side effects like nervousness or insomnia. It's advisable to limit caffeine intake during treatment.

Theophylline: Concurrent use with theophylline, a medication for respiratory conditions, may lead to increased theophylline levels, raising the risk of adverse effects. Monitoring and possible dosage adjustments are recommended.

Warfarin and Other Oral Anticoagulants: Ciprofloxacin can enhance the effects of blood thinners like warfarin, increasing bleeding risk. Regular monitoring of blood clotting parameters is advised.

Cyclosporine: Combining ciprofloxacin with cyclosporine, an immunosuppressant, may result in transient increases in serum creatinine levels. Renal function should be closely monitored in such cases.

Tizanidine: Ciprofloxacin can significantly elevate tizanidine levels, leading to increased sedative and blood pressure-lowering effects. Co-administration is generally contraindicated.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Combining NSAIDs with ciprofloxacin may heighten the risk of central nervous system stimulation and seizures. Caution is advised when using these medications together.

Phenytoin: Ciprofloxacin can alter phenytoin levels, either increasing or decreasing them, which may affect seizure control. Monitoring phenytoin levels is recommended during concurrent use.

Sucralfate: This medication can reduce the absorption of ciprofloxacin. It's advisable to take ciprofloxacin at least two hours before or six hours after sucralfate administration.

Probenecid: Co-administration may decrease the renal elimination of ciprofloxacin, leading to higher blood levels. Monitoring for increased ciprofloxacin effects is suggested.

Hormonal Contraceptives: Ciprofloxacin may reduce the effectiveness of hormonal contraceptives. Additional contraceptive measures are recommended during treatment.

Enteral Feedings: Tube feedings can decrease ciprofloxacin absorption. It's recommended to administer ciprofloxacin either two hours before or six hours after enteral feedings.

Contact Lenses: Avoid wearing contact lenses during treatment with Ciloxan, as the preservative benzalkonium chloride can be absorbed by soft lenses, potentially causing irritation.

Always inform your healthcare provider about all medications, supplements, and dietary habits to ensure safe and effective use of Ciloxan.