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The safety and warning information below is crucial for understanding the potential risks and safe use of this medication. Please read carefully and consult your healthcare provider with any questions or concerns.

• Serious Gut Problems (Colitis): Although rare, clindamycin can be absorbed through the skin and lead to a serious condition known as colitis, which is inflammation of the colon. Patients using opioid pain medications, such as hydrocodone/acetaminophen or oxycodone, or Lomotil (diphenoxylate/atropine) may have an increased risk of prolonged or worsening colitis. Risks are heightened when clindamycin/benzoyl peroxide is applied to the mouth, eyes, or broken skin, used for extended periods, or taken with opioids or Lomotil.

• Sunburn Risk: While using clindamycin/benzoyl peroxide, your skin may become more sensitive to UV light, increasing the risk of severe sunburn. Limit exposure to sunlight, sun lamps, and tanning beds during and right after treatment. Consider staying in the shade, wearing protective clothing, and consulting your dermatologist about appropriate sunscreen use.

• Skin Irritations: Using other topical acne treatments alongside clindamycin/benzoyl peroxide may cause skin irritation, including peeling and flaking. If irritation occurs, your dermatologist may advise temporarily reducing the frequency of application or stopping the treatment. For severe irritation, alternative treatments may be considered.

Contraindications:

This medication should not be used if any of the following conditions apply, as it may pose significant health risks. Always discuss with your healthcare provider first:

• Allergy to lincomycin
• History of certain inflammatory bowel conditions, such as ulcerative colitis, antibiotic-associated colitis, or regional enteritis.

Remember to always follow your healthcare provider's guidance when using this medication.

Using this medication can lead to some common side effects, such as mild skin redness, peeling, dryness, burning, and itching. These effects are usually not severe and often manageable with moisturizing creams or lotions. If these symptoms persist or worsen, consulting a healthcare provider is advisable to ensure safe usage.

In rare cases, the medication may be absorbed into the bloodstream, potentially causing a severe intestinal condition linked to the C. difficile bacteria. This condition can surface during or weeks to months after treatment. Symptoms include persistent diarrhea, abdominal pain or cramping, and blood or mucus in the stool. It is crucial not to use anti-diarrhea or opioid products in such scenarios, as they could exacerbate the symptoms. Immediate medical consultation is recommended if these symptoms occur.

A very serious allergic reaction to this drug is rare but requires immediate medical attention if it occurs. Symptoms of such a reaction include rash, itching or swelling (notably of the face, tongue, or throat), severe dizziness, and difficulty breathing.

While many people using this medication do not encounter serious side effects, staying informed and vigilant about changes in your condition is essential. If you notice any other effects not mentioned here, reaching out to your healthcare provider is prudent.