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When taking this medication, some people might experience mild side effects like constipation or an upset stomach. These are generally not serious, but if they persist or worsen, it's important to consult your healthcare provider. Most individuals using this medication do not encounter severe side effects. However, be vigilant for more serious symptoms, such as nausea, vomiting, loss of appetite, unusual weight loss, changes in mood or mental state, signs of kidney problems like altered urine output, bone or muscle pain, headaches, increased thirst and urination, feelings of weakness or tiredness, and a rapid or pounding heartbeat.

While a severe allergic reaction is rare, it is crucial to seek immediate medical attention if you experience symptoms such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. This list does not cover all possible side effects, so if you notice any other unusual symptoms, you should contact your healthcare provider. Remember, your doctor has assessed that the benefits of this medication outweigh the potential risks of side effects.

Certain medications may interact with this drug. These include Digoxin and phosphate binders. Calcium can reduce the effectiveness of other medications by decreasing their absorption. This affects tetracycline antibiotics like doxycycline and Minocycline, bisphosphonates such as Alendronate, as well as estramustine, Levothyroxine, and quinolone antibiotics like Ciprofloxacin and Levofloxacin. Additionally, some drugs can lower the absorption of vitamin D; these include bile acid sequestrants like Cholestyramine and Colestipol, Mineral Oil, and Orlistat. It is important to space out doses of these medications from your calcium/vitamin D doses. Consult your doctor or pharmacist to determine the appropriate time intervals between doses and to create a medication schedule that suits your needs.

Check the labels of all your prescription, over-the-counter, and herbal products (such as antacids, laxatives, and vitamins) for calcium, phosphate, or vitamin D content. Your pharmacist can advise you on the safe use of these products. Avoid using medications that contain Calcitriol while taking vitamin D, as they are very similar. This drug may also affect certain laboratory tests, such as cholesterol tests, potentially leading to inaccurate results. Inform your healthcare providers and lab personnel that you are taking this product.