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When using this medication, it's important to be aware of potential interactions and precautions to ensure your safety and the drug's effectiveness. Here are some key points to consider:

• Be cautious when using other products that could interact with this medication, notably antihistamines applied to the skin like diphenhydramine cream, ointment, or spray.
• Inform your healthcare provider if you are taking any products that may cause drowsiness. This includes opioid pain or cough medications (such as codeine or hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as alprazolam, lorazepam, zolpidem), muscle relaxants (like carisoprodol or cyclobenzaprine), and other antihistamines (such as cetirizine or diphenhydramine).
• Carefully review the labels of all your medications, including those for allergies or cough-and-cold, as they might contain ingredients that induce drowsiness. Consult your pharmacist for guidance on the safe use of these products.
• This medication has the potential to interfere with certain laboratory tests, such as allergy skin tests, leading to inaccurate results. It is essential to inform laboratory personnel and all your healthcare providers that you are using this medication to prevent misleading test outcomes.

By following these guidelines, you can help manage potential interactions and ensure the safe use of your medication.

Common side effects:

• Drowsiness
• Dizziness
• Headache
• Constipation
• Stomach upset
• Blurred vision
• Decreased coordination
• Dryness in the mouth, nose, or throat

Less common but important to monitor:

• Mental or mood changes (like hallucinations, irritability, nervousness, or confusion)
• Ringing in the ears
• Difficulty urinating
• Unusual bruising or bleeding
• Fast or irregular heartbeat
• Seizures

Serious side effects:

• Serious allergic reaction (rash, itching or swelling particularly of the face, tongue, or throat, severe dizziness, or trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Opioid pain or cough medications (such as codeine, hydrocodone)
• Alcohol
• Marijuana (cannabis)
• Drugs for sleep or anxiety (such as Alprazolam, Lorazepam, Zolpidem)
• Muscle relaxants (such as Carisoprodol, Cyclobenzaprine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray)
• Other antihistamines (such as Cetirizine, diphenhydramine)