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The following information outlines essential safety and warning details associated with the use of diphenhydramine (Benadryl). It is crucial to read these carefully and discuss any concerns with your healthcare provider.

• Risk of Accidental Overdose: Diphenhydramine is a common ingredient in many over-the-counter products. Avoid using more than one medication containing diphenhydramine simultaneously, including topical applications. Overconsumption can lead to symptoms like dry eyes or mouth, rapid heartbeat, difficulty urinating, fever, and constipation. More severe consequences may include severe confusion, seizures, low blood pressure, muscle spasms, hallucinations, and heart rhythm irregularities. Ensure you are not taking multiple products with diphenhydramine to prevent overdose.

• Excessive Drowsiness: Diphenhydramine often causes significant drowsiness, affecting concentration and reaction time. This is particularly hazardous for older adults (65 years and older) as it increases the risk of falls and may cause prolonged drowsiness into the following day. The sedative effects are heightened when combined with alcohol or other sedative medications such as opioids, benzodiazepines, and sleep aids. Refrain from activities requiring alertness, like driving or operating machinery, until you understand how this medication affects you.

• Potential Worsening of Health Conditions: Before using diphenhydramine, consult your provider if you have conditions such as glaucoma, an enlarged prostate, respiratory issues (e.g., emphysema), or kidney problems, as it may exacerbate these conditions and lead to severe side effects.

These guidelines are designed to ensure the safe use of diphenhydramine and mitigate potential risks. Always consult with a healthcare professional for personalized advice.

Common side effects:

• drowsiness
• dizziness
• headache
• dry mouth
• dry nose
• dry throat
• constipation
• blurred vision

Less common but important to monitor:

• nausea
• vomiting
• loss of appetite
• muscle weakness
• nervousness
• hyperactivity

Serious side effects:

• confusion
• restlessness
• pounding or irregular heartbeat
• ringing in the ears
• seizures
• difficulty urinating
• rash
• itching
• swelling of the face, lips, or throat
• severe dizziness
• trouble breathing
• seeing halos
• vision loss

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• opioid pain relievers or cough suppressants (e.g., codeine, hydrocodone)
• alcohol
• marijuana (cannabis)
• sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem)
• muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine)

Interactions with low risk that usually do not require a change in therapy:

• skin-applied antihistamines like diphenhydramine cream, ointment, or spray
• other antihistamines (e.g., Cetirizine, chlorpheniramine)