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This document provides crucial safety information regarding the use of cefixime (Suprax). It is important to understand and consider these warnings before starting the medication. Always consult with your healthcare provider if you have any questions or concerns.

• Allergic Reactions: Inform your healthcare provider if you have experienced allergic reactions to penicillin-type or cephalosporin antibiotics, characterized by symptoms such as difficulty breathing or facial swelling. Cefixime (Suprax) may not be suitable for you. If such symptoms occur after starting the medication, seek immediate medical help.

• C. Difficile Diarrhea: There is a rare risk of developing a serious bacterial infection causing severe diarrhea when taking antibiotics like cefixime (Suprax). This can occur up to two months after completing the antibiotic course. Contact your healthcare provider if you experience severe, watery diarrhea.

• Kidney Issues: Cefixime (Suprax) is excreted through the kidneys. Individuals with impaired kidney function or those on dialysis are at risk of increased drug accumulation, leading to potential side effects. Your healthcare provider will adjust your dosage based on kidney function tests.

• Increased Bleeding Risk: Cefixime (Suprax) may infrequently affect blood clotting. If you are using blood thinners, your dosage might need adjustment. Seek medical attention if you experience unusual bleeding or if wounds take longer to heal.

• Drug-Resistant Bacteria: Use cefixime (Suprax) strictly for bacterial infections. Misuse can contribute to the development of drug-resistant bacteria, complicating future treatments.

• Phenylketonuria (PKU) Concerns: The chewable form of this medication contains phenylalanine, which can be harmful to individuals with PKU. Discuss with your healthcare provider the safety of using this formulation if you or your child have PKU.

These warnings are intended to guide safe usage of cefixime (Suprax), ensuring effective treatment while minimizing potential risks. Always follow your healthcare provider's instructions and report any adverse effects promptly.

Common side effects:

• Stomach upset
• Diarrhea
• Nausea
• Gas
• Headache
• Dizziness

Less common but important to monitor:

• Oral thrush
• New yeast infection
• Abnormal liver or kidney function
• Seizures
• Abnormal blood cell counts
• Genital itching and inflammation

Serious side effects:

• Severe stomach or abdominal pain
• Persistent nausea or vomiting
• Yellowing of the skin or eyes
• Dark urine
• Unusual tiredness
• Persistent sore throat
• Fever
• Easy bruising or bleeding
• Changes in urine output
• Mental changes such as confusion
• Intestinal infection caused by C. difficile
• Rash
• Itching
• Swelling of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Warfarin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cholera Vaccine, Live
• Desogestrel
• Dienogest
• Drospirenone
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Gestodene
• Levonorgestrel
• Mestranol
• Nomegestrol
• Norethindrone
• Norgestimate
• Norgestrel