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This information outlines key safety considerations and warnings for the use of rabeprazole (Aciphex). It is crucial to review these details and discuss any concerns with your healthcare provider.

• Masking Serious Conditions: Frequent GERD symptoms could signal a more serious condition like stomach cancer. Inform your healthcare provider if GERD symptoms worsen or return after treatment, or if you experience poor appetite, unexplained weight loss, or weakness.

• Acute Kidney Issues: Although rare, some individuals on PPIs have developed sudden kidney inflammation. Seek medical advice if you notice changes in urination, experience nausea, weakness, fever, rash, or joint pain.

• Infectious Diarrhea: PPIs, including rabeprazole, may increase the risk of severe diarrhea, especially in those over 65, in healthcare facilities, or with weakened immune systems. Use the lowest effective dose for the shortest necessary duration. Report severe or watery diarrhea, fever, abdominal pain, loss of appetite, or nausea to your healthcare provider promptly.

• Bone Fracture Risk: Long-term or high-dose use of PPIs could heighten the risk of fractures in the hip, wrist, or spine. Discuss with your provider if you have osteoporosis or a history of fractures, and ensure the lowest effective dose for the shortest duration.

• Skin Reactions: Serious skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis, though rare, may occur. Symptoms include fever, body aches, rash, peeling skin, blisters, and facial swelling. Seek immediate medical attention if these occur.

• Lupus Symptoms: Use of rabeprazole may trigger or worsen lupus, identifiable by joint pain or rash. Symptoms often resolve within 1 to 3 months after discontinuing the medication. Stop use and consult your provider if symptoms arise.

• Vitamin B12 and Magnesium Deficiency: Long-term use (3 years or more) can result in deficiencies. Watch for signs such as dizziness, muscle weakness, pale skin, fatigue, or tingling in extremities, and discuss with your provider.

• Drug Interactions: Rabeprazole can affect the efficacy of other drugs, notably Edurant (rilpivirine), potentially reducing its effectiveness against HIV. Avoid concurrent use of these medications.

Contraindications:

• Do not use rabeprazole if you are taking Edurant (rilpivirine) or any medications containing rilpivirine, such as Complera, without consulting your healthcare provider.

Common side effects:

• Headache
• Sore throat
• Passing gas
• Infections
• Constipation

Less common but important to monitor:

• Belly pain
• Diarrhea
• Dry mouth
• Dizziness
• Swelling of the hands and feet
• Muscle or joint pain

Serious side effects:

• Severe stomach pain
• Persistent diarrhea
• Kidney problems
• Lupus-like symptoms
• Serious skin reactions
• Vitamin B-12 deficiency symptoms
• Severe allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Rilpivirine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acalabrutinib
• Amphetamine
• Atazanavir
• Benzphetamine
• Bosutinib
• Capecitabine
• Cilostazol
• Clopidogrel
• Dacomitinib
• Dasatinib
• Dextroamphetamine
• Digoxin
• Erlotinib
• Eslicarbazepine Acetate
• Gefitinib
• Ketoconazole
• Ledipasvir
• Lisdexamfetamine
• Methamphetamine
• Methotrexate
• Mycophenolate Mofetil
• Nelfinavir
• Neratinib
• Nilotinib
• Octreotide
• Pazopanib
• Pexidartinib
• Saquinavir
• Secretin Human
• Selpercatinib
• Sunitinib
• Velpatasvir
• Vismodegib

Interactions with low risk that usually do not require a change in therapy:

• Levothyroxine