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This safety and warning information is intended to provide crucial insights into the potential risks and necessary precautions when using this medication. Please read carefully and consult with your healthcare provider if you have any questions or concerns.

• Neurological Side Effects: Famotidine (Pepcid AC) may lead to neurological side effects such as confusion, delirium, hallucinations, agitation, seizures, and general weakness. Individuals with kidney issues are at an increased risk as their kidneys may struggle to effectively metabolize the medication, thereby increasing its levels in the blood and the likelihood of side effects. If you have any kidney-related conditions, discuss with your healthcare provider the possibility of adjusting your dosage of famotidine (Pepcid AC).

• Potential Cancer Risk: On rare occasions, persistent heartburn can be indicative of severe stomach issues, including cancer. Heartburn medications like famotidine (Pepcid AC) might mask these underlying signs. If heartburn symptoms persist after completing a course of treatment, it is vital to contact your healthcare provider for further evaluation to rule out serious conditions such as stomach cancer.

• Contraindications: You should not use this medication if you have a severe allergy to histamine-2 (H2) antagonists. Prior to starting treatment, consult your healthcare provider if you have experienced any allergic reactions to similar medications.

Always consult your healthcare provider before making any changes to your medication regimen, especially if you have pre-existing conditions or are experiencing unusual symptoms.

When taking this medication, you might experience some common side effects such as headaches, dizziness, constipation, or diarrhea. These are usually mild, but if they persist or worsen, it's important to consult your healthcare provider. Other side effects that have been reported include fever, fatigue, vomiting, nausea, an upset stomach, dry mouth, and dry skin. While these are not as common, they should be monitored, and any concerns should be discussed with your healthcare provider.

In rare cases, more serious side effects can occur. These include easy bruising or bleeding and signs of infection such as a persistent sore throat, fever, or chills. Mental and mood changes like restlessness, confusion, depression, or hallucinations have also been noted. If you experience any of these, contact your healthcare provider immediately.

Immediate medical attention is crucial if you encounter very serious side effects such as an irregular heartbeat, severe dizziness, fainting, or seizures. Though rare, serious allergic reactions can occur, characterized by a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing. If any of these symptoms appear, seek medical help right away. Always stay vigilant and report any new or worsening symptoms to your healthcare provider.

Famotidine may interact with certain medications. It reduces stomach acid, which can affect the absorption and effectiveness of some drugs. Medications affected include atazanavir, dasatinib, specific azole antifungals like itraconazole and ketoconazole, levoketoconazole, pazopanib, and sparsentan, among others. It is important not to take famotidine alongside other products containing famotidine or other H2 blockers such as cimetidine, nizatidine, or ranitidine.

Furthermore, there are certain medications that should not be used with famotidine. These include bepridil, cisapride, dofetilide, dronedarone, mesoridazine, pimozide, piperaquine, saquinavir, sparfloxacin, terfenadine, thioridazine, and ziprasidone. In some cases, using famotidine with other medications is not advisable but may be necessary. In such instances, your doctor may adjust the dosage or frequency. These medications include acalabrutinib, alfentanil, alprazolam, amiodarone, and many others. Always inform your healthcare provider about all the medications and supplements you are currently taking to avoid potential interactions.