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When taking this medication, you might experience some common side effects such as dry mouth, mild stomach upset, trouble sleeping, dizziness, headache, nervousness, loss of appetite, or increased thirst. These effects are usually mild and might not require medical attention unless they persist or worsen. It's important to monitor how you feel and consult a healthcare provider if any concerns arise.

While many individuals do not experience severe side effects, there are some serious ones to be aware of. Contact your healthcare provider immediately if you notice fast or irregular heartbeat, uncontrolled shaking or tremor, mental or mood changes such as confusion, or difficulty urinating. These symptoms require prompt medical evaluation to ensure your safety.

In rare cases, this medication may cause very serious side effects like seizures, and immediate medical attention is necessary. Additionally, though uncommon, a serious allergic reaction could occur. Symptoms to watch for include rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, or trouble breathing. These require urgent medical care.

It's crucial to stay informed about how your body responds to the medication. If you notice any effects not mentioned here or have any concerns, reach out to your healthcare provider to discuss them.

Avoid using this medication with MAO inhibitors, as this combination can lead to a severe, potentially life-threatening interaction. Refrain from taking MAO inhibitors like isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while on this medication. Additionally, most MAO inhibitors should be discontinued at least two weeks prior to starting this treatment. Consult with your doctor about the appropriate timing for starting or stopping this medication.

Be cautious with over-the-counter medications, particularly cough and cold products, as they may contain decongestants like phenylephrine, which could interact with this medication. Check with your pharmacist to ensure safe use.

Loratadine is closely related to Desloratadine, so avoid taking any medications containing desloratadine while using loratadine.

This medication may affect the results of certain laboratory tests, such as allergy skin tests, potentially leading to inaccurate results. Ensure that all healthcare providers and lab technicians are aware that you are using this medication.