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This document provides essential safety information and warnings for the use of dexchlorpheniramine (RyClora). Please review the following points carefully and consult your healthcare provider if you have any questions or concerns:

• Risk of Overdose with Antihistamines: Taking an excessive amount of antihistamines can be extremely dangerous, with potential outcomes including hallucinations, seizures, or even death. This risk is particularly elevated in children. Many over-the-counter cold and flu medications contain antihistamines like dexchlorpheniramine, so it's crucial to read medication labels to avoid taking multiple antihistamines simultaneously.

• Sleepiness and Impaired Reaction: Dexchlorpheniramine (RyClora) may cause drowsiness, impairing focus, cognition, or reaction times. This effect is more pronounced in older adults, those consuming alcohol while on the medication, or individuals taking other sedative medications such as opioids or benzodiazepines. Refrain from driving or operating heavy machinery until you understand how this medication affects you. Avoid alcohol consumption during treatment. Discuss potential drug interactions with your healthcare provider to ensure safe use.

• Exacerbation of Pre-existing Conditions: It is imperative to inform your healthcare team of all existing medical conditions before starting dexchlorpheniramine (RyClora). While it is an antihistamine, it also possesses anticholinergic properties that can aggravate conditions like glaucoma, hyperthyroidism, heart disease, high blood pressure, stomach ulcers, urinary retention issues, and an enlarged prostate.

• Contraindications: Do not use this medication if any of the following conditions apply, as it may result in serious health risks:

  • Newborn or premature infants
  • Individuals currently breastfeeding
  • Patients with lung problems such as asthma
  • Those currently taking or who have recently taken monoamine oxidase inhibitors (MAOIs)

If you ever suspect an overdose or experience severe side effects, seek emergency medical assistance immediately. Always consult your healthcare provider for personalized advice and before making any changes to your medication regimen.

Common side effects:

• Sleepiness
• Dizziness
• Stomach upset
• Blurry vision

Less common but important to monitor:

• Dry mouth
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Trouble urinating
• Double vision
• Weakness

Serious side effects:

• Rash
• Hives
• Itchiness
• Shortness of breath
• Chest tightness
• Swelling of the lips, tongue, face, or eyes

When taking dexchlorpheniramine, it's important to be aware of potential interactions with other substances that can enhance side effects or reduce the medication's effectiveness. Combining dexchlorpheniramine with other antihistamines, including those applied to the skin like diphenhydramine creams or sprays, can increase the risk of side effects such as drowsiness, dry mouth, and blurred vision.

Using dexchlorpheniramine alongside substances that cause drowsiness—such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or other antihistamines (e.g., Cetirizine, diphenhydramine)—can amplify drowsiness and impair your ability to perform tasks requiring alertness.

Additionally, dexchlorpheniramine may interact with medications like Promethazine, propofol, and Quetiapine, leading to increased sedation.

To minimize risks, inform your healthcare provider about all medications and supplements you are currently taking. Avoid consuming alcohol while on dexchlorpheniramine, and refrain from activities that require mental alertness, such as driving, until you understand how the medication affects you.

Always consult your doctor or pharmacist before starting, stopping, or changing the dosage of any medications to ensure safe and effective use.