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This document provides critical safety information regarding the use of benzocaine topical medication. Please read carefully, and consult your healthcare provider if you have any questions or concerns.

• Blood Oxygen Issues (Methemoglobinemia): This medication may rarely cause methemoglobinemia, a serious condition where blood fails to deliver enough oxygen throughout the body. Symptoms include headaches, dizziness, difficulty breathing, increased heart rate, fatigue, and pale or bluish skin, lips, and nail beds. The risk is heightened in young children, older adults, and individuals with heart or respiratory conditions. Symptoms can appear within minutes to a couple of hours after application, even if you have used benzocaine before without issues. If you experience these symptoms, seek medical attention immediately. Individuals at increased risk include those with breathing or heart issues, certain genetic conditions, smokers, and those taking medications or consuming foods with nitrates.

• Allergic Reactions to Topical Pain Relievers: Avoid using benzocaine topical if you have previously had allergic reactions to similar medications, such as procaine, bupivacaine, or topical lidocaine. Symptoms of an allergic reaction include hives, breathing difficulties, and swelling of the face, lips, or throat. If these occur, seek emergency medical care immediately.

Contraindications:

The following conditions indicate when benzocaine topical should not be used due to potential serious health risks. Discuss with your healthcare provider if any of these apply to you:

• Heart rhythm irregularities
• History of methemoglobinemia
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency
• Respiratory issues

Common side effects:

• Mild burning or stinging sensations

Serious side effects:

• Methemoglobinemia
• Serious allergic reactions

Benzocaine is a local anesthetic commonly used to relieve pain from minor skin irritations, sore throats, and dental issues. While it is generally safe for topical use, it's important to be aware of potential interactions with other substances that could increase the risk of side effects.

One significant concern is the risk of methemoglobinemia, a condition where the blood's ability to carry oxygen is reduced. This risk may be heightened when benzocaine is used alongside certain medications known to induce methemoglobinemia. These include:

• Nitrates and Nitrites: Medications such as Nitroglycerin and nitroprusside.

• Local Anesthetics: Other anesthetics like Lidocaine, Bupivacaine, and prilocaine.

• Antibiotics: Drugs like Dapsone and sulfonamides.

• Antimalarials: Medications such as chloroquine and Primaquine.

• Anticonvulsants: Drugs including Phenytoin and Phenobarbital.

Combining benzocaine with these substances can increase the likelihood of developing methemoglobinemia. Symptoms to watch for include a bluish or grayish color of the skin, lips, or nails, shortness of breath, fatigue, and dizziness. If you experience any of these symptoms, seek medical attention immediately.

Additionally, using benzocaine with other local anesthetics may lead to excessive numbing or irritation. It's advisable to avoid combining benzocaine with other topical anesthetics unless directed by a healthcare professional.

Before using benzocaine, inform your healthcare provider about all medications, supplements, and herbal products you are currently taking. This will help prevent potential interactions and ensure the safe use of benzocaine.