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Metoclopramide

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generic Reglan, Gimoti

Metoclopramide, commonly known as Reglan, is a medication primarily used to treat nausea and vomiting caused by surgery or chemotherapy, and to address gastroparesis in individuals with diabetes. This condition, characterized by delayed stomach emptying, can lead to symptoms like nausea, vomiting, and abdominal fullness, which metoclopramide helps alleviate. Additionally, it is approved for managing severe acid reflux (GERD) when other treatments are ineffective. The drug functions by blocking dopamine, a natural substance in the brain that influences various bodily functions, including those of the digestive system. This action not only prevents nausea and vomiting but also accelerates stomach emptying and upper intestinal movement. However, metoclopramide is not the first-choice treatment for all conditions due to the risk of serious side effects, such as tardive dyskinesia—a movement disorder. It is also advised against use in children under one year old due to potential severe side effects. Patients are encouraged to consult healthcare providers for personalized advice, especially because metoclopramide can interact with other medications like risperidone and quetiapine. Always seek professional guidance before starting or changing treatment regimens.
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2ML of 5MG/ML, Metoclopramide (1 Syringe)

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CVS

$19.64

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$1.01

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$2.00

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$4.70

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Metoclopramide dosage forms

The average cost for 1 Syringe of Metoclopramide (generic Reglan, Gimoti) at 2ML of 5MG/ML is $1.01 with a free coupon. This is 6.78% off the average retail price of $14.9
DosageQuantityPrice fromPer unit
2ML of 5MG/ML1 Syringe$1.01$1.01

Metoclopramide Warnings

Metoclopramide, commonly known as Reglan, is associated with several serious side effects and risks. It's crucial to understand these potential risks and precautions to ensure safe usage. Here is a summary of the key safety information:

  • Tardive Dyskinesia (TD): This medication can cause a severe movement disorder known as tardive dyskinesia, which involves uncontrolled movements of the tongue, face, mouth, lips, hands, arms, legs, and feet. The risk of developing TD increases with prolonged use, especially in older adults, women, and individuals with diabetes. Avoid combining metoclopramide with other medications that may cause TD, like prochlorperazine or haloperidol. If you notice any uncontrollable movements, contact your healthcare provider immediately as these symptoms can become permanent.

  • Other Movement Disorders: Metoclopramide may cause other movement-related symptoms such as muscle stiffness, tremors, and restlessness, particularly within the first six months of treatment. These symptoms typically resolve after discontinuation of the medication but may take up to three months to subside completely. Seek medical attention if these occur.

  • Neuroleptic Malignant Syndrome (NMS): There is a risk of developing NMS, a rare but life-threatening condition characterized by high fever, muscle stiffness, confusion, rapid or irregular heartbeat, and excessive sweating. Stop the medication and seek emergency medical help if these symptoms appear. The risk is heightened when taken with antipsychotic medications.

  • Mental Health Changes: The use of metoclopramide may induce depression or suicidal thoughts, even in those without a prior history of depression. Report any mood changes or suicidal ideations to your healthcare provider immediately.

  • High Blood Pressure: This medication can increase blood pressure, particularly if used alongside other medications that have a similar effect, such as MAOIs. Monitor your blood pressure regularly and consult your healthcare provider if any significant changes occur.

  • Fluid Retention and Swelling: Metoclopramide can elevate aldosterone levels, leading to fluid retention and swelling in the arms, legs, or abdomen. This is a particular concern for individuals with heart failure or liver issues. Report any unexpected swelling or rapid weight gain to your healthcare provider.

  • Elevated Prolactin Levels: The medication can increase prolactin levels, resulting in symptoms like milky discharge from the nipples, enlarged breasts, or irregular menstrual cycles. Discuss any such symptoms with your healthcare provider.

Contraindications: Metoclopramide should not be used in individuals with uncontrolled body movements, stomach bleeding or blockages, tumors that affect blood pressure, or a history of seizures. Always consult your healthcare provider before starting this medication to ensure it is safe for your use.

In case of an overdose, seek immediate medical assistance. These guidelines are essential to prevent adverse effects and ensure the safe use of metoclopramide. Always discuss any concerns or potential interactions with your healthcare provider.

Metoclopramide Side Effects

Common side effects:

  • Drowsiness
  • Dizziness
  • Tiredness
  • Restlessness
  • Headaches
  • Flushing
  • Diarrhea
  • Lack of energy

Less common but important to monitor:

  • Trouble sleeping
  • Nervousness
  • Depression
  • Hallucinations
  • Changes in blood pressure
  • Swelling in arms, legs, or around the belly
  • Enlarged breasts
  • Leaky nipples
  • Irregular menstrual periods
  • Changes in heart rate
  • Changes in liver function
  • Changes in urination
  • Changes in blood health

Serious side effects:

  • Uncontrolled muscle movements (tardive dyskinesia)
  • Neuroleptic malignant syndrome (NMS)
  • Suicidal thoughts
  • Seizures
  • Severe allergic reactions (rash, itching, or swelling)

Metoclopramide Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Metoclopramide FAQs
What is metoclopramide generally used for?

Metoclopramide is generally used to treat nausea and vomiting, facilitate gastric emptying in patients with gastroparesis, and manage gastroesophageal reflux disease (GERD) when other treatments are not effective. It works by increasing the movements or contractions of the stomach and intestines.

Metoclopramide and Zofran (ondansetron) are not the same. They are different medications used to treat nausea and vomiting, but they work through different mechanisms and are used in different clinical situations. Metoclopramide is a dopamine receptor antagonist, while Zofran is a serotonin 5-HT3 receptor antagonist.

The main side effect of metoclopramide is drowsiness. Other common side effects can include fatigue, restlessness, and, in some cases, involuntary muscle movements. It is important for patients to discuss any side effects with their healthcare provider.

Metoclopramide is not typically classified as a high-risk drug, but it does have potential side effects and risks that need to be considered. It can cause serious side effects such as tardive dyskinesia, especially with long-term use or high doses. Therefore, it should be used with caution, and patients should be monitored for any adverse effects. It is important for healthcare providers to evaluate the benefits and risks before prescribing metoclopramide.

Metoclopramide can be effective in reducing or stopping vomiting. It works by enhancing the movement of the stomach and intestines, which helps to prevent nausea and vomiting. However, its effectiveness can vary depending on the underlying cause of the vomiting. It is important for individuals to consult with a healthcare provider to determine if metoclopramide is appropriate for their specific situation.