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The safety and warning information for the use of Synera (lidocaine/tetracaine) is crucial for safeguarding your health. Please review the following points carefully and consult your healthcare provider if you have any questions or concerns.

• Methemoglobinemia Risk: This medication can cause methemoglobinemia, a condition where your blood's ability to deliver oxygen is impaired. Symptoms include skin turning blue, difficulty breathing, fatigue, seizures, coma, or even death. Prompt medical attention is necessary if you experience these symptoms. Higher risk groups include individuals with G6PD deficiency, heart or lung conditions, a history of methemoglobinemia, or infants under 6 months.

• Overdose Warning: Overuse of Synera can lead to severe side effects such as breathing difficulties, heart issues, coma, or cardiac arrest. Use the medication strictly as prescribed, avoiding prolonged use or multiple patches. Never apply the patch to damaged skin.

• Risk to Children and Pets: Ingesting or chewing the patches can be harmful to children and pets. Ensure the patches are stored out of their reach and dispose of them safely according to the provided instructions.

• Eye Irritation: Contact with eyes can cause significant irritation. Wash hands thoroughly after handling and rinse eyes immediately if contact occurs. Seek medical advice if irritation persists.

• Severe Allergic Reactions: If you experience hives, swelling, or difficulty breathing, these might signal a severe allergic reaction. Immediate medical help is recommended.

Contraindications: Do not use Synera if you have allergies to lidocaine, tetracaine, other local anesthetics, or para-aminobenzoic acid (PABA). Always consult your healthcare provider before use if you have these conditions.

When using this medication, several side effects may occur. Common side effects include skin redness, experienced by 71% of users, along with whitish or pale skin coloring and swelling, both affecting around 12% of users. These side effects are generally mild, but if they persist or become bothersome, it is advisable to consult a healthcare provider.

In addition to the common side effects, other reactions such as itching, rash, and skin discoloration have been reported. While these are not as frequent, it's important to monitor these symptoms and seek medical advice if necessary, especially if they worsen.

More serious side effects, though rare, demand immediate medical attention. These include severe blood problems like methemoglobinemia, which can manifest as seizures, loss of consciousness, rapid heartbeat, difficulty breathing, dizziness, fatigue, and changes in skin color to blue or pale. Serious allergic reactions may also occur, leading to facial swelling, breathing difficulties, trouble speaking, throat constriction, a red and itchy rash, lightheadedness, and clammy skin. If you experience any of these severe symptoms, seek urgent medical care.