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This medication may infrequently lead to serious, potentially life-threatening liver issues, often occurring within the first six months of therapy. It is crucial to conduct lab tests before commencing treatment and at regular intervals afterward, particularly during the initial six months, to detect this side effect.

• Children under two years of age face an increased risk of severe liver problems, particularly if they have inherited metabolic disorders, severe seizure disorders with mental retardation, organic brain disease, or are taking multiple seizure medications. Consult with a healthcare provider to weigh the risks and benefits of administering this medication to children under two.
• Individuals with specific inherited metabolic disorders, such as Alpers-Huttenlocher syndrome, should not use this medication due to heightened liver risk. Children under two years suspected of having these disorders must avoid this drug, while older children should be closely monitored during treatment with divalproex sodium. Speak with a healthcare professional for detailed guidance.

This medication has also been associated with rare but severe pancreatic disease (pancreatitis), which can occur at any time during treatment and may rapidly deteriorate.

• Promptly inform your doctor if you experience persistent nausea or vomiting, unusual fatigue, weakness, facial swelling, abdominal pain, appetite loss, dark urine, or yellowing of the skin or eyes, as these may be symptoms of liver issues or pancreatitis.

Using this medication during pregnancy can cause birth defects, potentially reduce the child's IQ, and increase the risk of brain or mental disorders such as autism or ADHD.

• Men and women using this medication should discuss its risks and benefits, alternative treatments, and reliable birth control methods with a healthcare provider. If planning a pregnancy or if pregnancy occurs or is suspected, consult your doctor immediately.
• For those taking divalproex sodium solely for migraine prevention, it must not be used during pregnancy. If prescribed for seizures or mental health conditions like bipolar disorder, do not discontinue use without medical advice, as these conditions are serious and can harm both the pregnant individual and the unborn child.

When taking this medication, you might experience mild side effects such as diarrhea, dizziness, drowsiness, hair loss, blurred or double vision, changes in menstrual periods, ringing in the ears, tremors, unsteadiness, or weight changes. These are generally manageable, but if they persist or worsen, consult your healthcare provider. Occasionally, you may notice partial tablets in your stool, particularly if you have certain intestinal conditions. Report this to your healthcare provider promptly.

In rare instances, some individuals on anticonvulsants may face severe mental health issues like depression or suicidal thoughts. It’s important to seek immediate medical attention if you notice any sudden changes in mood or behavior. Rarely, a serious brain disorder called encephalopathy can occur, especially in those with specific metabolic disorders. If you experience unexplained weakness, vomiting, or sudden mental changes, contact your healthcare provider immediately.

Seek urgent medical help if you encounter severe side effects such as chest pain, unusual bruising or bleeding, irregular heartbeat, swelling of hands or feet, uncontrolled eye movements, feeling cold or shivering, rapid breathing, or loss of consciousness. Although a very serious allergic reaction is rare, watch for symptoms like fever, swollen lymph nodes, rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. If you experience any of these, seek medical assistance right away. Always stay informed and report any new side effects to your healthcare provider.