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The following safety information outlines critical warnings and precautions related to the use of ethosuximide (Zarontin). It is crucial to understand these risks and discuss any concerns with your healthcare provider.

• Low Blood Cell Counts: Ethosuximide (Zarontin) can cause a decrease in blood cell counts, particularly white blood cells and platelets. This may increase your susceptibility to infections and bleeding. Although rare, these effects can be serious. Regular monitoring by your healthcare provider is advised.

• Liver and Kidney Damage: This medication may lead to liver or kidney damage, which might not present immediate symptoms. Regular blood and urine tests will be conducted to monitor organ function. Inform your healthcare provider if you have a history of liver or kidney issues for closer monitoring.

• Lupus Risk: Some patients may develop lupus, an autoimmune condition, while taking ethosuximide (Zarontin). Symptoms include fatigue, fever, muscle and joint pain, and a facial rash. Contact your healthcare provider if you experience these symptoms or have concerns about this risk.

• Suicidal Thoughts or Behavior: There is an increased risk of suicidal thoughts or behavior when taking ethosuximide (Zarontin) and similar antiepileptic drugs. Monitor for any new or worsening symptoms of depression or mood changes, and seek immediate help if you have thoughts of self-harm.

• Severe Allergic Reactions: Rare, but severe allergic reactions can occur, including skin reactions, fever, swollen lymph nodes, and swelling of the face or mouth. Seek immediate medical attention if you experience these symptoms or have difficulty breathing.

• Risk of Seizures Upon Sudden Discontinuation: Do not stop taking ethosuximide (Zarontin) abruptly, as this may trigger seizures. Always consult your healthcare provider before making changes to your medication regimen.

• Treatment for Absence Seizures Only: Ethosuximide (Zarontin) is specifically for absence seizures and may exacerbate other seizure types. Patients with mixed seizure types may require additional antiepileptic medications. Discuss suitable treatment options with your healthcare provider.

Contraindication:

• Do not use ethosuximide (Zarontin) if you have an allergy to Celotin (methsuximide). Always inform your healthcare provider of any allergies before starting new medications.

Common side effects:

• drowsiness
• dizziness
• tiredness
• headache
• stomach upset
• nausea
• vomiting
• weight loss
• diarrhea
• loss of coordination

Less common but important to monitor:

• poor appetite
• difficulty concentrating
• stomach cramps
• difficulty with movement or walking
• feeling unusually happy
• irritability
• hyperactivity
• difficulty sleeping
• nightmares
• aggressiveness

Serious side effects:

• symptoms of low blood cell counts
• frequent infections
• unusual tiredness
• shortness of breath
• easy bruising or nosebleeds
• allergic reactions like severe rashes, hives, blisters
• swelling of the face or throat
• mood changes, including depression or suicidal thoughts

Interactions with high risk of serious adverse effects and should be avoided:

• Calcifediol
• Fosphenytoin
• Phenytoin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Ginkgo
• Nevirapine
• Phenobarbital
• Valproic Acid

Interactions with low risk that usually do not require a change in therapy:

• Orlistat