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Naratriptan is a medication used to treat migraines, but it carries certain risks and precautions that should be carefully considered. Below is a summary of important safety information and warnings related to its use.

• Heart-Related Risks: Usage of naratriptan can occasionally lead to significant heart issues, including heart attacks and irregular heartbeats, especially within hours of taking the medication. It may also cause a dangerous increase in blood pressure. Individuals with a history of heart problems, those over 65, people with diabetes, obesity, high blood pressure, and smokers are at increased risk.

• Stroke and Brain Injuries: There is a risk of serious brain events, such as strokes or bleeding, particularly in those with a history of strokes. It is crucial to inform your healthcare provider about any previous strokes or brain injuries before using this medication.

• Blood Vessel Constriction: Naratriptan can cause severe narrowing of blood vessels, resulting in significant issues in the stomach (such as pain or bloody diarrhea), vision changes, or altered sensations in the extremities. If you experience symptoms like color changes in your hands or feet, stop taking the medication and consult with your healthcare provider immediately.

• Medication Overuse Headaches: Excessive use of naratriptan can lead to a decrease in its effectiveness and may result in more frequent migraine attacks. If you find yourself needing the medication more than 9 days a month or experience more than 4 migraines monthly, discuss alternative treatments with your healthcare provider.

• Serotonin Syndrome: Although rare, there is a possibility of developing serotonin syndrome, a potentially life-threatening condition, when taking naratriptan, especially if combined with other drugs that increase serotonin levels.

Contraindications indicate circumstances where naratriptan should not be used due to the potential for severe health risks:

• Coronary artery disease or vasospasm, including Prinzmetal's angina.
• Certain arrhythmias, like Wolff-Parkinson-White syndrome.
• History of stroke or transient ischemic attack (mini-stroke).
• Uncontrolled high blood pressure.
• Peripheral vascular disease or ischemic bowel disease.
• Recent use of ergot-based medications or other triptans within the last 24 hours.
• Current or recent (within 14 days) use of monoamine oxidase inhibitors (MAOIs).
• Severe kidney or liver impairments.

Always consult your healthcare provider before starting naratriptan, especially if any of these conditions apply to you.

Common side effects:

• nausea
• flushing
• tingling
• numbness
• prickling
• heat sensations
• weakness
• tiredness
• dizziness
• drowsiness
• sleepiness
• "pins and needles" feeling
• pain or pressure in throat or neck

Serious side effects:

• chest, jaw, or left arm pain
• shortness of breath
• unusual sweating
• fast or irregular heartbeat
• fainting
• severe stomach pain
• bloody diarrhea
• sudden weakness on one side of the body
• severe headache
• changes in speech or vision
• confusion
• serotonin syndrome
• rash
• itching
• swelling of the face, tongue, or throat
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Almotriptan
• Bromocriptine
• Dihydroergotamine
• Eletriptan
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Frovatriptan
• Linezolid
• Methylergonovine
• Methysergide
• Rizatriptan
• Sumatriptan
• Tranylcypromine
• Zolmitriptan

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alfentanil
• Amineptine
• Amitriptyline
• Amitriptylinoxide
• Amoxapine
• Amphetamine
• Benzhydrocodone
• Benzphetamine
• Buprenorphine
• Butorphanol
• Citalopram
• Clomipramine
• Codeine
• Desipramine
• Desvenlafaxine
• Dextroamphetamine
• Dibenzepin
• Dihydrocodeine
• Dolasetron
• Doxepin
• Duloxetine
• Escitalopram
• Fenfluramine
• Fentanyl
• Fluoxetine
• Fluvoxamine
• Furazolidone
• Granisetron
• Hydrocodone
• Hydromorphone
• Imipramine
• Iproniazid
• Isocarboxazid
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Lisdexamfetamine
• Lithium
• Lofepramine
• Lorcaserin
• Melitracen
• Meperidine
• Metaxalone
• Methadone
• Methamphetamine
• Methylene Blue
• Milnacipran
• Mirtazapine
• Moclobemide
• Morphine
• MorphineSulfate Liposome
• Nalbuphine
• Nefazodone
• Nortriptyline
• Ondansetron
• Opipramol
• Oxycodone
• Oxymorphone
• Palonosetron
• Paroxetine
• Pentazocine
• Phenelzine
• Procarbazine
• Protriptyline
• Rasagiline
• Reboxetine
• Remifentanil
• Selegiline
• Sertraline
• Sibutramine
• St John's Wort
• Sufentanil
• Tapentadol
• Tianeptine
• Tramadol
• Trazodone
• Trimipramine
• Tryptophan
• Venlafaxine
• Vilazodone
• Vortioxetine
• Ziprasidone