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This document provides crucial safety information regarding the use of this medication. Review the following warnings carefully and consult with your healthcare provider for any concerns you may have.

• Dehydration: Ethacrynic acid (Edecrin) promotes urination to eliminate excess fluids, which can lead to dehydration and increased thirst. This risk is heightened with high doses of ethacrynic acid.

• Electrolyte Imbalance: The use of ethacrynic acid may alter electrolyte levels such as sodium, potassium, magnesium, and chloride. Regular blood tests may be necessary to monitor these levels. Increased risk is associated with existing kidney problems, concurrent use of medications affecting electrolytes, high doses, or a strict low-salt diet.

• Low Blood Pressure: This medication can cause a drop in blood pressure upon standing, resulting in lightheadedness or dizziness. This is more likely if you are taking other blood pressure medications, consuming alcohol, or are exposed to high temperatures. If dizziness persists, consult your prescriber, who may adjust your dosage or suggest an alternative treatment.

• Hearing Issues: Ethacrynic acid may result in temporary ear ringing or hearing loss, which usually resolves within a day. Permanent hearing damage is rare but may occur, particularly with existing kidney issues, excessive dosing, the injectable form of the drug, or concurrent use of other ototoxic medications.

• Severe Diarrhea: Sudden, severe, watery diarrhea may occur. Immediately inform your prescriber if you experience this, as further medical evaluation may be required.

• Gout Attacks: There is a possibility of gout flare-ups in some individuals. Notify your healthcare provider if you have a history of gout or are experiencing symptoms, allowing for close monitoring of your condition.

• Elevated Blood Sugar: Though rare, some patients may experience increased blood sugar levels. Those with diabetes should discuss with their healthcare provider whether more frequent blood sugar monitoring is necessary.

Contraindications:

This medication should not be used under certain conditions due to the potential for severe health risks. Consult your healthcare provider if any of the following apply to you:

• Inability to urinate.
• Experience of severe, watery diarrhea.
• Use in infants.

When taking this medication, you may experience some common side effects such as dizziness, lightheadedness, headache, feeling tired or weak, and stomach discomfort, including diarrhea and nausea. These symptoms are generally mild, but if they persist or worsen, consult your healthcare provider. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

In some cases, users may notice ringing in the ears, temporary hearing loss, blurry vision, or a rash. If these occur, monitor them closely and seek advice if they become bothersome. Less common side effects include low appetite and trouble swallowing, which should also be reported if they persist.

More serious side effects, though rare, require immediate medical attention. These include symptoms of dehydration or abnormal electrolyte levels, such as severe weakness, muscle cramps, a fast heartbeat, or confusion. Severely low blood pressure can cause fainting, severe dizziness, or blurry vision. Additionally, high uric acid levels and changes in blood sugar levels have been noted. If you experience severe, watery diarrhea, or any signs of an allergic reaction like rash, itching, or trouble breathing, seek urgent care. Always stay attentive to your body's reactions and report any unusual symptoms to your healthcare provider.

Ethacrynic Acid, also known as Edecrin, can have interactions with various medications and supplements. It's crucial to inform your doctor and pharmacist about all medications and supplements, whether they are prescribed, over-the-counter, vitamins, or herbal products, that you are currently taking.

Some drugs, such as Desmopressin, should not be used with ethacrynic acid. Your doctor might choose to prescribe an alternative treatment or adjust your current medications.

There are other medications, like Furosemide and Lithium, that are generally not recommended to be taken with ethacrynic acid. In certain situations, if these medications are necessary, your doctor may adjust the dosage or frequency.

Additionally, some medications, although having a potential risk of enhancing side effects, might be used together if considered beneficial for your treatment. In such cases, your doctor may tweak how you use these medications. Examples include certain blood pressure medications like ACE inhibitors (e.g., Captopril, Lisinopril) and other substances including Ginseng and licorice.

Always make sure to discuss any concerns or questions with your healthcare provider to ensure safe and effective use of ethacrynic acid.