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Here is an important summary of the safety information and warnings associated with the use of Ethacrynic acid (Edecrin). Please read carefully and discuss any concerns with your healthcare provider:

• Dehydration: Ethacrynic acid promotes urination to eliminate excess fluids, which can lead to dehydration and increased thirst. This risk is heightened with high doses.

• Electrolyte Imbalance: This medication can alter levels of vital electrolytes such as sodium, potassium, magnesium, and chloride. Regular blood tests may be necessary to monitor these levels, especially if you have existing kidney issues, are on medications affecting electrolytes, are consuming a high dose, or are on a low-salt diet.

• Low Blood Pressure: Ethacrynic acid may cause a drop in blood pressure upon standing, leading to dizziness or lightheadedness. This is more likely if you are also on blood pressure-lowering drugs, consume alcohol, or overheat. Persistent symptoms should be reported to your healthcare provider, who may adjust your dose or suggest an alternative treatment.

• Hearing Issues: The medication may cause ringing in the ears or temporary hearing loss, usually resolving within a day. Permanent hearing damage is rare but more likely with kidney problems, high doses, or the injection form of this drug, or if combined with other hearing-affecting medications.

• Severe Diarrhea: Sudden, severe watery diarrhea can occur. Immediate medical attention is necessary if this develops while using the medication to determine its cause and seriousness.

• Gout Flare-ups: There is a risk of gout attacks in some patients. Inform your healthcare provider if you have a history of gout for close monitoring.

• Elevated Blood Sugar: Rare cases of increased blood sugar levels have been reported. Patients with diabetes should consult their healthcare provider about the frequency of blood sugar monitoring while on this medication.

Contraindications: Ethacrynic acid should not be used in the following situations due to potential severe health risks:

• Complete inability to urinate.
• Severe, watery diarrhea.
• Use in infants.

Always consult your healthcare provider if any of these conditions apply to you before starting this medication.

Common side effects:

• Dizziness
• Lightheadedness
• Headache
• Feeling tired or weak
• Low blood pressure
• Ringing in the ears
• Temporary hearing loss
• Blurry vision
• Upset stomach
• Diarrhea
• Nausea
• Vomiting
• Low appetite

• Skin rash

  Less common but important to monitor:

• Changes in blood sugar levels
• High uric acid levels
• Dehydration

• Electrolyte imbalances

  Serious side effects:

• Severe dehydration
• Severely low blood pressure
• Severe diarrhea
• Allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Desmopressin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Furosemide
• Lithium
• NSAIDs (e.g., Ibuprofen, Naproxen)