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This medication contains critical ingredients, including acetaminophen, which can pose serious health risks if not used correctly. Please review the following safety information to ensure safe use and consult your healthcare provider if you have any concerns.

• Liver Damage: Excessive intake of acetaminophen can lead to severe, potentially fatal liver damage. Adults should not exceed 4 grams of acetaminophen within 24 hours. Individuals with liver conditions and children should take a reduced dosage. Consult your healthcare provider to determine a safe amount. Avoid simultaneous use with other acetaminophen-containing medications without professional advice. Acetaminophen is present in many over-the-counter and prescription medications, so check your labels carefully and ask your pharmacist if unsure. Immediate medical assistance is necessary if an overdose occurs, even without symptoms. Overdose indicators include nausea, vomiting, appetite loss, sweating, stomach pain, fatigue, yellowing skin or eyes, and dark urine.

• Alcohol Interaction: Regular alcohol consumption, especially if combined with acetaminophen, can harm your liver. It is advisable to avoid alcohol while taking this medication.

• Reye's Syndrome: Aspirin, another ingredient, should not be given to children recovering from flu-like symptoms due to the risk of Reye's syndrome, a rare but severe condition. Symptoms include vomiting, headache, and confusion, potentially progressing to seizures. Consult a physician for suitable alternatives for children.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible. If you experience hives, breathing difficulties, or swelling of the lips or tongue, seek emergency assistance immediately. Inform your healthcare provider of any aspirin or NSAID allergies before starting this medication.

• Stomach Issues: Aspirin can irritate the stomach, leading to stomach pain, heartburn, bleeding, or ulcers. If you experience persistent pain, vomit blood, or have bloody stools, discontinue use and seek medical attention. These symptoms may indicate a serious condition.

• Kidney Concerns: Aspirin may also cause kidney damage, especially in combination with certain blood pressure medications. Watch for signs of reduced urination, fever, muscle weakness, or a rapid heartbeat. Discontinue use and inform your healthcare provider if these occur.

• Dehydration: The caffeine content can lead to dehydration, particularly at high doses. Ensure adequate fluid intake and consult your provider if dehydration symptoms occur.

• Pre-existing Conditions: Avoid this medication if you have certain pre-existing conditions unless approved by your healthcare provider, as it may exacerbate issues. Discuss any medical history with your provider.

• Overdose Risks: Taking excessive acetaminophen or NSAIDs can result in serious health complications. Monitor your intake, especially if using multiple products containing these ingredients. If overdose is suspected, contact medical services or the Poison Control Center immediately.

• Contraindications: This medication should not be used if you have an allergy to aspirin or other NSAIDs, or if you have asthma, nasal inflammation, or polyps. It is not recommended for children under specific age guidelines or used concurrently with other acetaminophen-containing medications. Consult your healthcare provider under these conditions.

When using this medication, you may encounter some common side effects, such as nausea, vomiting, stomach upset, or trouble sleeping. A feeling of nervousness or restlessness might also occur. These effects are generally mild, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

Some individuals might experience serious side effects that require immediate medical attention. These include severe stomach or abdominal pain, dizziness, fainting, or vomiting that resembles coffee grounds. Additionally, be alert for black or bloody stools, ringing in the ears, or any loss of hearing, as well as signs of kidney issues like changes in urine output or easy bruising and bleeding. Furthermore, symptoms indicative of liver problems, such as dark urine, yellowing of the skin or eyes, and severe fatigue, should be addressed immediately.

Rare but severe allergic reactions can occur, characterized by symptoms like fever, swollen lymph nodes, rash, itching, and swelling of the face, tongue, or throat. If you experience difficulty breathing or severe dizziness, seek medical help promptly. Other concerning symptoms include unusual bruising, blistering of the skin, or red and dark patches that might itch or blister.

This summary does not cover all possible side effects, so if you notice any unlisted symptoms, contacting your healthcare provider is recommended.

Certain medications can interact with this drug, potentially affecting its efficacy or increasing side effects. These include acetazolamide, cimetidine, corticosteroids like prednisone, dichlorphenamide, ketoconazole, levoketoconazole, methotrexate, mifepristone, medications for gout such as probenecid, anti-seizure drugs like phenytoin and valproic acid, and vemurafenib. If you have recently received live vaccines, such as the varicella or intranasal influenza vaccines, consult your doctor before using this product.

Taking this medication with other drugs that increase bleeding risk, such as anti-platelet agents like clopidogrel or blood thinners including dabigatran, enoxaparin, and warfarin, can heighten the risk of bleeding. It is crucial to review all of your medications, including over-the-counter ones, as many contain ingredients like acetaminophen, aspirin, and NSAIDs such as ibuprofen, ketorolac, and naproxen, which may lead to additional side effects when combined with this drug. Discuss with your healthcare provider or pharmacist for more guidance.

Moreover, this medication may interfere with certain laboratory tests, such as urinary sugar tests and dipyridamole-thallium imaging tests, leading to potentially inaccurate results. Ensure that all medical personnel and your healthcare providers are aware that you are taking this medication.