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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as salsalate, have potential risks that should be carefully considered. Although low-dose aspirin is not included in these risks, NSAIDs may infrequently raise the likelihood of experiencing a heart attack or stroke. This risk is present at any point during the use of the medication but is more pronounced with prolonged use. Individuals with heart disease or those at an elevated risk for heart disease—due to factors such as smoking, a family history of heart disease, high blood pressure, or diabetes—may face a greater risk. It is important to avoid taking this medication immediately before or after having coronary artery bypass graft (CABG) surgery.

Additionally, NSAIDs, including salsalate, may infrequently lead to severe and potentially fatal bleeding in the stomach or intestines. This bleeding can occur unexpectedly at any time during treatment.

Please be vigilant and stop using the medication, seeking immediate medical assistance if you experience any of the following uncommon but severe side effects:

• Persistent stomach or abdominal pain
• Chest pain
• Severe dizziness
• Weakness on one side of the body
• Sudden vision changes
• Difficulty speaking
• Black stools
• Vomit resembling coffee grounds

For more information, consult the Precautions section. It is crucial to discuss the advantages and risks of using this medication with your doctor or pharmacist.

You may experience mild side effects such as an upset stomach, dizziness, or nausea. These are generally not serious, but if they persist or worsen, consult your healthcare provider. Monitoring your blood pressure is important while on this medication, as it may cause an increase. If your blood pressure readings are consistently high, inform your doctor.

Serious side effects, although uncommon, require immediate attention. These include heartburn, changes in hearing (like ringing in the ears or hearing loss), easy bruising or bleeding, a rapid or pounding heartbeat, and signs of infection such as a persistent sore throat or fever. Be alert for symptoms indicating kidney issues like changes in urination or signs of heart failure such as swelling in the ankles or feet, unusual tiredness, or sudden weight gain.

In rare cases, this medication can cause severe liver disease, which can be fatal. Seek urgent medical help if you experience persistent nausea or vomiting, dark urine, yellowing of the eyes or skin, appetite loss, or abdominal pain. Although a severe allergic reaction is rare, watch for symptoms like a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, and get emergency assistance if they occur.

This is not an exhaustive list of side effects. If you notice any other unusual symptoms, reach out to your doctor or pharmacist for advice.

Certain medications can interact with this drug, including Aliskiren, ACE inhibitors like Captopril and Lisinopril, and angiotensin II receptor blockers such as Losartan and Valsartan. Seizure medications like Phenytoin and Valproic Acid, as well as Cidofovir, corticosteroids (e.g., Prednisone), and dichlorphenamide, may also interact. Additionally, medications for gout such as Probenecid, drugs that alter urine acidity like Ammonium Chloride and Acetazolamide, Lithium, Methotrexate, pemetrexed, and tenofovir are included.

Taking this medication with others that increase bleeding risk, such as anti-platelet drugs like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, and Warfarin, can further raise the risk of bleeding.

Be sure to review all your prescription and over-the-counter medications, as many contain pain relievers or fever reducers (NSAIDs like Aspirin, Ibuprofen, Ketorolac, or Naproxen) similar to this drug, which may heighten side effects if used together. If your doctor has advised you to take low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue doing so unless otherwise directed by your doctor. Consult your doctor or pharmacist for further guidance.

This medication might affect certain lab tests, such as urine glucose or thyroid hormone levels, potentially leading to inaccurate results. Ensure all healthcare providers and laboratory staff are aware that you are using this medication.