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Deferasirox is a medication that requires careful consideration due to its potential risks and necessary precautions. Below is a summary of essential safety information and warnings:

• Kidney Risks: Deferasirox may lead to severe kidney issues, particularly in individuals with pre-existing kidney conditions, severe blood disorders, or those taking other medications that affect kidneys. Young children and those who are dehydrated are also at increased risk. These kidney problems can be life-threatening, potentially leading to kidney failure. Regular monitoring by your healthcare provider is crucial.

• Liver Concerns: The medication can cause serious liver problems, especially in older adults, those with liver issues such as cirrhosis, or individuals with organ failure. Liver complications can also occur in dehydrated children. It is important to discuss any history of liver conditions with your healthcare provider before starting treatment.

• Stomach and Intestinal Bleeding: Older adults with serious blood diseases may experience life-threatening stomach bleeding when taking deferasirox. The risk is heightened if you are also taking NSAIDs, corticosteroids, bisphosphonates, or blood thinners. Be vigilant for symptoms like severe stomach pain, black tarry stools, or blood in urine, and seek immediate medical attention if they occur.

• Blood Cell Concerns: Deferasirox might lower blood cell levels, posing a risk, particularly for those with existing blood disorders. Regular blood tests will be conducted to monitor your blood cell counts. Report any signs of bleeding or infection, such as frequent fevers or prolonged nosebleeds, to your healthcare provider.

• Iron Levels: There is a risk of removing too much iron from the blood, which can adversely affect kidney and liver health. Your provider will adjust your dose to the lowest effective level and monitor iron levels regularly, especially if you are receiving blood transfusions or have non-transfusion dependent thalassemia (NTDT).

• Skin Reactions: Some individuals may experience rashes or severe skin reactions. Mild rashes often resolve independently, but severe reactions require immediate medical consultation. Stop taking the medication if you develop blisters, skin peeling, or high fever, and seek medical help.

• Vision and Hearing Issues: Deferasirox can cause vision or hearing problems, particularly in children on higher doses. Regular eye exams and hearing tests are recommended before and during treatment. If you notice any changes in vision or hearing, contact your provider promptly.

• Contraindications: Deferasirox should not be used by individuals with moderate to severe kidney disease, high-risk myelodysplastic syndromes, aggressive tumors or advanced blood cancers, severely low platelet counts, or poor physical performance status.

Ensure you communicate openly with your healthcare provider about any pre-existing conditions or medications you take to manage your safety effectively while on deferasirox.

When taking this medication, some common side effects may include diarrhea, stomach pain, nausea, vomiting, and dizziness. These are generally mild, but if they persist or worsen, it's advisable to consult your healthcare provider. Additionally, some individuals may experience higher protein levels in their urine, higher creatinine levels in their blood, skin rash, sleep problems, anxiety, or a change in skin color. While these side effects can be concerning, they are often manageable with appropriate care.

It's important to be aware of more serious side effects that, although rare, require immediate medical attention. These include symptoms of sudden kidney injury such as feeling sick or weak, dehydration, urinating less than usual, or swelling in the legs. Liver damage can present as tiredness, loss of appetite, dark urine, or yellowing of the eyes and skin. Stomach bleeding may manifest as stomach pain, black or tarry stools, and blood in the urine. Low blood cell counts can lead to frequent infections, easy bruising, or nosebleeds that don't stop.

Severe skin reactions, though rare, are serious and include symptoms like rash, skin pain or peeling, blisters, fever, sore throat, and facial swelling. Blurry vision, hearing loss, and throat pain also warrant prompt medical evaluation. Remember that allergic reactions, while very rare, require urgent care if you experience severe dizziness, trouble breathing, or swelling, particularly of the face, tongue, or throat. If you notice any other unusual effects, it's important to contact your healthcare provider for further guidance.

Deferasirox can interact with several medications, which may affect how the drugs work or increase the risk of side effects. It's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements.

Some drugs that may interact with Deferasirox include fezolinetant and anticoagulants like clopidogrel, NSAIDs such as ibuprofen or naproxen, and blood thinners like dabigatran or warfarin, which can increase bleeding risk. If your doctor has advised you to take low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention, continue unless instructed otherwise by your doctor.

This medication can also slow down the elimination of other drugs from your body, potentially altering their effectiveness. For example, this may impact drugs such as tovorafenib. Additionally, Deferasirox might reduce the effectiveness of hormonal contraceptives like pills, patches, or rings, possibly leading to pregnancy. It is advisable to consult your doctor about using additional reliable birth control methods while on this medication and report any unexpected spotting or bleeding.

Use of Deferasirox with other specific medications, such as aluminum-based compounds, amiodarone, busulfan, cholesterol-lowering agents like cholestyramine, and others like rifampin and warfarin, should generally be avoided unless necessary. Your doctor may need to adjust dosages if these are used together. In some cases, combining Deferasirox with repaglinide may increase the risk of side effects, and your doctor might modify the treatment plan accordingly.