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The following safety information outlines important warnings associated with the use of this medication. It is crucial to review these details and discuss any concerns with your healthcare provider.

• Low Blood Sugar Levels: This medication may cause dangerously low blood sugar levels, especially if combined with other glucose-lowering drugs like insulin, or if taken without food. You may need to monitor your blood sugar more frequently when starting treatment. Be aware of symptoms such as shakiness, anxiety, rapid heartbeat, excessive sweating, chills, confusion, and severe hunger. Factors increasing this risk include skipping meals, irregular eating schedules, alcohol consumption, intense physical activity, other medications that lower blood sugar, advanced age, and kidney or liver issues.

• Risk of Hemolytic Anemia: Individuals with low levels of glucose-6-phosphate dehydrogenase (G6PD) may experience decreased red blood cell counts, known as hemolytic anemia. If you have a genetic predisposition to this condition, your healthcare provider may recommend an alternative treatment. Symptoms to watch for include weakness, fatigue, and dizziness.

• Potential Heart Problems: There is a possible link between sulfonylureas and increased risk of heart-related fatalities, as suggested by studies on similar medications. Report any signs of a heart attack, such as chest pain, sweating, nausea, or dizziness, or symptoms of heart failure like difficulty breathing, fatigue, swelling, or sudden weight gain, to your provider immediately. Hospitalization and discontinuation of the medication might be necessary.

• Risk with Stomach Problems (Extended-Release Tablets): The extended-release form of this medication has a coating that does not dissolve, posing a risk for those with gastrointestinal issues, such as strictures, who may struggle to pass this coating. If you have these conditions, avoid using extended-release tablets.

Contraindications: Do not use this medication if you have any of the following conditions, as it may lead to serious health complications:

• Allergy to sulfonamide medications
• Type 1 diabetes
• Diabetic ketoacidosis

For any of these conditions or if you suspect an overdose, seek immediate medical attention and consult your healthcare provider without delay.

When taking this medication, you may experience some common side effects like nausea, vomiting, diarrhea, constipation, upset stomach, headache, and weight gain. These are generally mild and should not cause alarm. However, if they persist or worsen, consult your healthcare provider. Dizziness, nervousness, tremors, and passing gas are also possible and typically not concerning unless they become bothersome.

Be aware of more serious side effects that require prompt medical attention. These include signs of infection such as persistent sore throat or fever, easy bleeding or bruising, symptoms of liver issues like stomach pain, yellowing of the skin or eyes, and dark urine. Additionally, report any unusual tiredness, sudden weight gain, mental changes, swelling of hands or feet, and seizures to your doctor immediately.

Low blood sugar, or hypoglycemia, is a potential side effect characterized by sudden sweating, shaking, rapid heartbeat, hunger, blurred vision, dizziness, or tingling sensations. To manage this, keep glucose tablets or a quick source of sugar handy, such as candies or fruit juice. Conversely, symptoms of high blood sugar include increased thirst and urination, which should also be addressed with your healthcare provider, as adjustments to your treatment may be needed.

Allergic reactions are rare but serious. Seek immediate medical help if you experience a rash, severe itching or swelling, especially of the face, tongue, or throat, along with dizziness or trouble breathing. Always inform your healthcare provider about any side effects you encounter, as this list may not cover all potential reactions.

Before starting, stopping, or changing any medication, it's important to discuss with your doctor or pharmacist how it may impact your blood sugar levels. Regular blood sugar monitoring is crucial, and any symptoms of high or low blood sugar should be reported to your doctor immediately. Adjustments to your diabetes medication, exercise routine, or diet may be necessary.

Certain medications, such as beta-blockers like metoprolol, propranolol, and glaucoma eye drops containing timolol, can interfere with your ability to recognize the usual rapid or pounding heartbeat that signals low blood sugar (hypoglycemia). However, other symptoms like dizziness, hunger, or sweating are not affected by these drugs.

When taking Glipizide, it's essential to inform your doctor and pharmacist about any other medications or supplements you are using, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Some medications, such as Acarbose, Aspirin, certain antibiotics like Ciprofloxacin, and diabetes-related medications like Sitagliptin, can interact with Glipizide. These interactions might necessitate dosage adjustments or changes in how often you take your medications.

Additionally, combining Glipizide with certain other drugs, such as beta-blockers like Atenolol or Metoprolol, as well as supplements like Bitter Melon or Fenugreek, may increase the risk of side effects. In such cases, your healthcare provider may modify the dosage or frequency of these medications to ensure optimal treatment outcomes.