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This medication carries important safety information regarding potential risks and necessary precautions. It is essential to carefully review these details and discuss any concerns with your healthcare provider.

• Low Blood Sugar: Glimepiride (Amaryl) can significantly lower blood sugar levels, leading to symptoms such as shakiness, anxiety, rapid heartbeat, sweating, confusion, or extreme hunger. It is crucial for you and your family to understand how to manage low blood sugar and when to seek emergency assistance. Regular monitoring of blood sugar levels is advised, and it is recommended to keep fast-acting sugars handy at all times. Factors that increase risk include skipping meals, irregular eating schedules, alcohol consumption, intense physical activity, and usage of other blood sugar-lowering medications. Individuals over 60 and those with kidney or liver issues are also at higher risk.

• Serious Allergic Reactions: There is a risk of severe allergic reactions, including skin rashes, swelling, breathing difficulties, and dizziness, particularly in individuals with a history of sulfa drug allergies. Inform your healthcare provider of any previous allergic reactions to sulfa medications. Discontinue use and seek immediate medical attention if an allergic reaction occurs.

• Risk of Hemolytic Anemia: Patients with a deficiency in glucose-6-phosphate dehydrogenase (G6PD) may be at risk of developing hemolytic anemia when taking medications like glimepiride. If you have this genetic condition, your provider may consider alternative treatments. Report symptoms such as weakness, fatigue, or dizziness to your healthcare provider.

• Possible Heart Problems: Previous studies on similar medications suggest a potential increase in heart-related mortality risk. Although more research is needed for glimepiride, it is important to inform your healthcare provider if you experience symptoms of heart issues, such as chest pain, sweating, nausea, or difficulty breathing. Hospitalization and discontinuation of the medication may be necessary.

Contraindications: This medication should not be used by individuals with a known allergy to glimepiride or other sulfa medications, as it may pose significant health risks. Consult with your healthcare provider if you have any of these conditions before starting the medication.

Common side effects:

• Nausea
• Headache
• Dizziness
• Shakiness
• Anxiety
• Flu-like symptoms
• Fever
• Cough

Less common but important to monitor:

• Low blood sugar
• Weight gain

Serious side effects:

• Severe allergic reactions
• Yellowing of the eyes or skin
• Abdominal pain
• Dark urine
• Unusual tiredness
• Easy bruising
• Signs of infection
• Persistent sore throat

Interactions with high risk of serious adverse effects and should be avoided:

• Aspirin
• Balofloxacin
• Besifloxacin
• Chloroquine
• Ciprofloxacin
• Desmopressin
• Disopyramide
• Dulaglutide
• Enoxacin
• Entacapone
• Fleroxacin
• Flumequine
• Gatifloxacin
• Gemifloxacin
• Hydroxychloroquine
• Isoniazid
• Lanreotide
• Levofloxacin
• Lixisenatide
• Lomefloxacin
• Metreleptin
• Miconazole
• Moxifloxacin
• Nadifloxacin
• Norfloxacin
• Octreotide
• Ofloxacin
• Pasireotide
• Pazufloxacin
• Pefloxacin
• Pioglitazone
• Porfimer
• Prulifloxacin
• Rufloxacin
• Sitagliptin
• Sparfloxacin
• Thioctic Acid
• Tosufloxacin
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acebutolol
• Aminolevulinic Acid
• Atenolol
• Betaxolol
• Bisoprolol
• Bitter Melon
• Carteolol
• Carvedilol
• Celiprolol
• Colesevelam
• Esmolol
• Fenugreek
• Furazolidone
• Glucomannan
• Guar Gum
• Iproniazid
• Isocarboxazid
• Labetalol
• Levobunolol
• Linezolid
• Methylene Blue
• Metipranolol
• Metoprolol
• Moclobemide
• Nadolol
• Nebivolol
• Nialamide
• Oxprenolol
• Penbutolol
• Phenelzine
• Pindolol
• Practolol
• Procarbazine
• Propranolol
• Psyllium
• Rasagiline
• Safinamide
• Saxagliptin
• Selegiline
• Sotalol
• Timolol
• Tranylcypromine